Home

MYD88 (human)

Overview MYD88 Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: plasma membrane; endosome membrane; cytosol Molecular Function: identical protein binding; protein binding; death receptor binding; Toll binding Biological Process: nerve growth factor receptor signaling pathway; positive regulation of interleukin-23 production; positive regulation of smooth muscle cell proliferation; positive regulation of JNK cascade; response to molecule of fungal origin; signal transduction; activation of NF-kappaB transcription factor; cell surface receptor linked signal transduction; positive regulation of lymphocyte proliferation; response to peptidoglycan; lipopolysaccharide-mediated signaling pathway; JNK cascade; interferon type I biosynthetic process; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interleukin-17 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of chemokine biosynthetic process; regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immunoglobulin mediated immune response Reference #:  Q99836 (UniProtKB) Alt. Names/Synonyms: MYD88; MYD88D; myeloid differentiation primary response gene (88); Myeloid differentiation primary response protein MyD88 Gene Symbols: MYD88 Molecular weight: 33,233 Da Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MYD88 2JS7 - A=146-296 (human) 2Z5V - A=148-296 (human) 3MOP - F/A/D/C/E/B=20-117 (human) 4DOM - A=157-296 (human) 4EO7 - A=157-296 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2JS7 2Z5V 3MOP 4DOM 4EO7  |  Phospho3D  |  DISEASE 602170 612260  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S34	MRVRRRLSLFLNVRT
0	1		Q67	EIRQLETQADPTGRL
0	5		K95-u	RLLELLTkLGRDDVL
2	0		Y257-p	KRLIPIKyKAMKKEF
0	5		Y276-p	RFITVCDyTNPCTKS

	mouse
S34-p	VGVRRRLsLFLNPRT
R67-m2	EIRELETrPDPTRSL
L95	RLLELLALLDREDIL
Y257-p	KRLIPIKyKAMKKDF
Y276	RFITICDYTNPCTKS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.