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CEACAM1 (human)

Overview CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Immunoglobulin superfamily; Cell adhesion Cellular Component: membrane; integral to plasma membrane; extracellular region; integral to membrane; plasma membrane Molecular Function: protein binding Biological Process: integrin-mediated signaling pathway; cell migration; angiogenesis; homophilic cell adhesion Reference #:  P13688 (UniProtKB) Alt. Names/Synonyms: antigen CD66; BGP; BGP-1; BGP1; BGPI; Biliary glycoprotein 1; biliary glycoprotein adhesion molecule; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a antigen; CEACAM1; CEAM1 Gene Symbols: CEACAM1 Molecular weight: 57,560 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CEACAM1 2GK2 - A/B=34-141 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T457‑p, S461‑p, T492‑p, S494‑p cell growth, altered: S508‑p cytoskeletal reorganization: T492‑p, S494‑p activation: S508‑p inhibition: T457‑p, S461‑p molecular association, regulation: Y493‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		F454	ALACFLHFGKtGRAs
3	0		T457-p	CFLHFGKtGRAsDQR
2	0		R459	LHFGKtGRAsDQRDL
1	0		S461-p	FGKtGRAsDQRDLTE
1	0		T492-p	PNKMNEVtysTLNFE
7	1		Y493-p	NKMNEVtysTLNFEA
1	0		S494-p	KMNEVtysTLNFEAQ
8	0		S508-p	QQPTQPTsASPSLTA
2	37		Y520-p	LTATEIIysEVKKQ_
0	2		S521-p	TATEIIysEVKKQ__

	CEACAM1 iso2
F454	ALACFLHFGKtGsSG
T457-p	CFLHFGKtGsSGPLQ
S459-p	LHFGKtGsSGPLQ__
G461	FGKtGsSGPLQ____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	CEACAM1 iso9
F389	ALACFLHFGKTGSSG
T392	CFLHFGKTGSSGPLQ
S394	LHFGKTGSSGPLQ__
G396	FGKTGSSGPLQ____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S449	GLAYFLYSRKSGGGS
S452	YFLYSRKSGGGSDQR
G454	LYSRKSGGGSDQRDL
S456	SRKSGGGSDQRDLTE
A487	PNKVDDVAyTVLNFN
Y488-p	NKVDDVAyTVLNFNS
T489	KVDDVAyTVLNFNSQ
S503-p	QQPNRPTsAPSSPRA
Y515-p	PRATETVysEVKKK_
S516-p	RATETVysEVKKK__

	rat
S449-p	ALAYFLYsRKTGGGS
T452	YFLYsRKTGGGSDHR
G454	LYsRKTGGGSDHRDL
S456	sRKTGGGSDHRDLTE
S487	PNKVDDVSySVLNFN
Y488-p	NKVDDVSySVLNFNA
S489	KVDDVSySVLNFNAQ
S503-p	QQSKRPTsASSSPTE
Y513-p	SSPTETVySVVKKK_
S514	SPTETVySVVKKK__

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