Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CEACAM1 (human)

Overview
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Immunoglobulin superfamily; Motility/polarity/chemotaxis; Cell adhesion
Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; protein homodimerization activity
Biological Process: integrin-mediated signaling pathway; cell migration; angiogenesis; homophilic cell adhesion
Reference #:  P13688 (UniProtKB)
Alt. Names/Synonyms: antigen CD66; BGP; BGP-1; BGP1; BGPI; Biliary glycoprotein 1; biliary glycoprotein adhesion molecule; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a antigen; CEACAM1; CEAM1
Gene Symbols: CEACAM1
Molecular weight: 57,560 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CEACAM1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: T457‑p, S461‑p, T492‑p, S494‑p
cell growth, altered: S508‑p
cytoskeletal reorganization: T492‑p, S494‑p
activity, induced: S508‑p
activity, inhibited: T457‑p, S461‑p
molecular association, regulation: Y493‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 - gap
4 0 T457-p CFLHFGKtGRAsDQR
3 0 - gap
1 0 S461-p FGKtGRAsDQRDLTE
1 0 T492-p PNKMNEVtysTLNFE
8 1 Y493-p NKMNEVtysTLNFEA
1 0 S494-p KMNEVtysTLNFEAQ
9 0 S508-p QQPTQPTsAsPSLTA
0 1 S510-p PTQPTsAsPSLTATE
3 37 Y520-p LTATEIIysEVKKQ_
0 2 S521-p TATEIIysEVKKQ__
  CEACAM1 iso8  
- gap
T457-p CFLHFGKtGsSGPLQ
S459-p LHFGKtGsSGPLQ__
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
  CEACAM1 iso9  
- gap
T392 CFLHFGKTGSSGPLQ
S394 LHFGKTGSSGPLQ__
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
  mouse

 
S449 GLAYFLYSRKSGGGS
S452 YFLYSRKSGGGSDQR
- gap
S456 SRKSGGGSDQRDLTE
- gap
Y488-p NKVDDVAyTVLNFNS
T489 KVDDVAyTVLNFNSQ
S503-p QQPNRPTsAPSSPRA
P505 PNRPTsAPSSPRATE
Y515-p PRATETVysEVKKK_
S516-p RATETVysEVKKK__
  rat

 
S449-p ALAYFLYsRKTGGGS
T452 YFLYsRKTGGGSDHR
- gap
S456 sRKTGGGSDHRDLTE
S487 PNKVDDVSySVLNFN
Y488-p NKVDDVSySVLNFNA
S489 KVDDVSySVLNFNAQ
S503-p QQSKRPTsASSSPTE
S505 SKRPTsASSSPTETV
Y513-p SSPTETVySVVKKK_
S514 SPTETVySVVKKK__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.