Home

PANX1 (human)

Overview PANX1 Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; gap junction; integral to membrane; plasma membrane Molecular Function: actin filament binding; leak channel activity; protein heterodimerization activity; calcium channel activity; gap junction hemi-channel activity; receptor binding Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP Reference #:  Q96RD7 (UniProtKB) Alt. Names/Synonyms: innexin; MGC21309; MRS1; pannexin 1; Pannexin-1; PANX1; PX1; UNQ2529 Gene Symbols: PANX1 Molecular weight: 48,050 Da Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states

Select Structure to View Below PANX1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y10-p	IAQLATEyVFSDFLL
0	1		Y150-p	MEELDKVyNRAIKAA
0	1		S182	VTENLGQSLWEVSES
0	1		Y193-p	VSESHFKyPIVEQyL
0	2		Y199-p	KyPIVEQyLKTkkNS
0	1		K203-a	VEQyLKTkkNSNNLI
0	1		K204-a	EQyLKTkkNSNNLII
0	1		K212-a	NSNNLIIkYISCRLL
0	1		K307-u	RQKTDVLkVYEILPT
0	1		K381-u	KMDVVDGkTPMsAEM
0	1		S385-p	VDGkTPMsAEMREEQ
0	1		N394	EMREEQGNQTAELQG
0	1		K409-u	MNIDSETkANNGEKN

	mouse
Y10-p	IAHLATEyVFSDFLL
Y150	MEELDKVYNRAIKAA
S181-p	VTENVGQsLWEISES
Y192-p	ISESHFKyPIVEQyL
Y198-p	KyPIVEQyLKTKKNS
K202	VEQyLKTKKNSSHLI
K203	EQyLKTKKNSSHLIM
K211	NSSHLIMKYISCRLV
K306	RQKTDILKVYEILPT
-	under review
-	under review
S394-p	TKGEDQGsQRVEFKD
A409	LDLSSEAAANNGEKN

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.