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Protein Page:
CYP24A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP24A1 Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.13.126; EC 1.14.-.-; Oxidoreductase; Mitochondrial
Cellular Component: mitochondrial inner membrane
Molecular Function: iron ion binding; heme binding; 25-hydroxycholecalciferol-24-hydroxylase activity; oxidoreductase activity; 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity
Biological Process: osteoblast differentiation; steroid metabolic process; vitamin metabolic process; response to vitamin D; xenobiotic metabolic process; vitamin D metabolic process; vitamin D catabolic process
Reference #:  Q07973 (UniProtKB)
Alt. Names/Synonyms: 1,25-@dihydroxyvitamin D3 24-hydroxylase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; CP24; CP24A; CYP24; CYP24A1; Cytochrome P450 24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; exo-mitochondrial protein; MGC126273; MGC126274; P450-CC24; vitamin D 24-hydroxylase; Vitamin D(3) 24-hydroxylase
Gene Symbols: CYP24A1
Molecular weight: 58,875 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
Select Structure to View Below

CYP24A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20-p AFLQQLRsPRQPPRL
0 1 S35-p VTSTAYTsPQPREVP
0 1 K165-ac VRSAFQKkLMKPGEV
0 3 Y220-p ESICLVLyEKRFGLL
0 1 K378 LRNMPYLKACLKESM
0 1 T388-p LKESMRLtPSVPFTt
0 1 T395-p tPSVPFTtRTLDkAT
0 1 K400-ub FTtRTLDkATVLGEy
0 1 Y407-p kATVLGEyALPKGTV
0 2 S504-p HSGTLVPsRELPIAF
  mouse

 
D20 AFLRRLRDLGQPPRS
K35 VTSKAHVKRAPKEVP
K165 VRSAFQKKLMKPVEI
Y220 ESICLVLYEKRFGLL
K378-ub VRNMPYLkACLKESM
T388 LKESMRLTPSVPFTT
T395 TPSVPFTTRTLDKPT
K400 FTTRTLDKPTVLGEY
Y407 KPTVLGEYTLPKGTV
S504 HLGILVPSRELPIAF
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