Home

RRAGD (human)

Overview RRAGD Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: G protein regulator, misc. Cellular Component: lysosome; cytoplasm; nucleus Molecular Function: protein binding; GTP binding; protein heterodimerization activity Biological Process: positive regulation of TOR signaling pathway Reference #:  Q9NQL2 (UniProtKB) Alt. Names/Synonyms: bA11D8.2.1; DKFZp761H171; FLJ44176; Rag D; Rag D protein; RagD; Ras-related GTP binding D; Ras-related GTP-binding protein D; RRAGD Gene Symbols: RRAGD Molecular weight: 45,588 Da Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RRAGD 2Q3F - A/B=60-239 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2	______MSQVLGKPQ
0	1		S44	SSDADPDSGTEEGVL
0	1		-	gap
0	2		K80-u	SGKSSIQkVVFHKMS
0	4		T97-p	ETLFLEStNKICRED
0	3		T391-p	LQKKKRAtPNGTPRV

	mouse
S2-p	______MsQVLGKPQ
S43-g	SSDAELDsGPEEGEs
S50-g	sGPEEGEsRRNSWMP
K129-u	SGKSSIQkVVFHKMS
T146	ETLFLESTNRICRED
T440-p	LPKKTGAtPNGTPRV

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.