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Protein Page:
RRAGD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RRAGD Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 6q15-q16
Cellular Component: lysosome; cytoplasm; nucleus
Molecular Function: protein binding; GTP binding; protein heterodimerization activity
Biological Process: positive regulation of TOR signaling pathway
Reference #:  Q9NQL2 (UniProtKB)
Alt. Names/Synonyms: bA11D8.2.1; DKFZp761H171; FLJ44176; Rag D; Rag D protein; RagD; Ras-related GTP binding D; Ras-related GTP-binding protein D; RRAGD
Gene Symbols: RRAGD
Molecular weight: 45,588 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RRAGD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2 ______MSQVLGKPQ
0 1 S44 SSDADPDSGTEEGVL
0 1 - gap
0 2 K80-ub SGKSSIQkVVFHKMS
0 10 S96-p NETLFLEstNKICRE
0 8 T97-p ETLFLEstNKICRED
0 3 T391-p LQKKKRAtPNGTPRV
  mouse

 
S2-p ______MsQVLGKPQ
S43-gl SSDAELDsGPEEGEs
S50-gl sGPEEGEsRRNSWMP
K129-ub SGKSSIQkVVFHKMS
S145 SETLFLESTNRICRE
T146 ETLFLESTNRICRED
T440-p LPKKTGAtPNGTPRV
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