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MEK2 (mouse)

Overview MEK2 a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, dual-specificity; EC 2.7.12.2; Protein kinase, STE; STE group; STE7 family Cellular Component: Golgi apparatus; peroxisomal membrane; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; intercellular junction; cell cortex; cytosol; perinuclear region of cytoplasm; late endosome; nucleus Molecular Function: nucleotide binding; protein kinase activity; PDZ domain binding; MAP kinase kinase activity; transferase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; protein complex scaffold; kinase activity; ATP binding Biological Process: regulation of stress-activated MAPK cascade; activation of MAPK activity; MAPKKK cascade; protein amino acid phosphorylation; phosphorylation Reference #:  Q63932 (UniProtKB) Alt. Names/Synonyms: AA589381; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; MK2; Mkk2; MP2K2; OTTMUSP00000018442; Prkmk2; protein kinase, mitogen activated, kinase 2, p45 Gene Symbols: Map2k2 Molecular weight: 44,402 Da Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MEK2 1S9I - A/B=55-400 (human) 4H3Q - A=1-360 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		T13	KPVLPALTINPTIAE
0	4		S23	PTIAEGPSPTSEGAS
0	1		S26	AEGPSPTSEGASEAN
0	1		K40	NLVDLQKKLEELDLD
0	1		R51	LDLDEQQRKRLEAFL
0	1		K61	LEAFLTQKAKVGELK
0	1		K63	AFLTQKAKVGELKDD
0	2		K68	KAKVGELKDDDFERI
0	1		S76-p	DDDFERIsELGAGNG
0	1		K88-u	GNGGVVTkARHRPSG
0	1		S94	TkARHRPSGLIMARK
0	9		K101	SGLIMARKLIHLEIK
0	12		K108	KLIHLEIKPAVRNQI
0	27		K196-u	QIMHRDVkPSNILVN
0	12		K209	VNSRGEIKLCDFGVs
2	4		S216-p	KLCDFGVsGQLIDsM
41	58		S222-p	VsGQLIDsMANsFVG
6	0		S222-a	VsGQLIDsMANsFVG
42	187		S226-p	LIDsMANsFVGTRSY
2	0		S226-a	LIDsMANsFVGTRSY
0	1		D285	SFGRPVVDGADGEPH
0	3		S293-p	GADGEPHsVsPRPRP
0	7		S295-p	DGEPHsVsPRPRPPG
1	1		S306	RPPGRPISVGHGMDS
0	1		K362-u	PAERADLkLLMNHAF
0	1		S373	NHAFIKRSEGEEVDF
0	5		S394-p	TLRLKQPstPTRTAV
0	71		T395-p	LRLKQPstPTRTAV_
1	13		T397	LKQPstPTRTAV___
1	0		T399	QPstPTRTAV_____

	human
T13-a	KPVLPALtINPTIAE
S23-p	PTIAEGPsPTsEGAS
S26-p	AEGPsPTsEGASEAN
K40-u	NLVDLQKkLEELELD
K51-u	LELDEQQkKRLEAFL
K61-u	LEAFLTQkAkVGELk
K63-u	AFLTQkAkVGELkDD
K68-u	kAkVGELkDDDFERI
S76	DDDFERISELGAGNG
K88	GNGGVVTKVQHRPsG
S94-p	TKVQHRPsGLIMARk
K101-u	sGLIMARkLIHLEIk
K108-u	kLIHLEIkPAIRNQI
K196-u	QIMHRDVkPSNILVN
K209-u	VNSRGEIkLCDFGVs
S216-p	kLCDFGVsGQLIDsM
S222-p	VsGQLIDsMANsFVG
S222-a	VsGQLIDsMANsFVG
S226-p	LIDsMANsFVGTRSY
S226-a	LIDsMANsFVGTRSY
D285-ca	IFGRPVVdGEEGEPH
S293-p	GEEGEPHsIsPRPRP
S295-p	EGEPHsIsPRPRPPG
S306-p	RPPGRPVsGHGMDSR
K361	PAERADLKMLTNHTF
S372-p	NHTFIKRsEVEEVDF
G393	TLRLNQPGtPtRtAV
T394-p	LRLNQPGtPtRtAV_
T396-p	LNQPGtPtRtAV___
T398-p	QPGtPtRtAV_____

	rat
T13	KPVLPALTINPTIAE
S23	PTIAEGPSPTSEGAS
S26	AEGPSPTSEGASEAH
K40	HLVDLQKKLEELDLD
R51	LDLDEQQRKRLEAFL
K61	LEAFLTQKAKVGELK
K63	AFLTQKAKVGELKDD
K68	KAKVGELKDDDFERI
S76	DDDFERISELGAGNG
K88	GNGGVVTKARHRPSG
S94	TKARHRPSGLIMARK
K101	SGLIMARKLIHLEIK
K108	KLIHLEIKPAVRNQI
K196-u	QIMHRDVkPSNILVN
K209	VNSRGEIKLCDFGVS
S216	KLCDFGVSGQLIDsM
S222-p	VSGQLIDsMANsFVG
S222-a	VSGQLIDsMANsFVG
S226-p	LIDsMANsFVGTRSY
S226	LIDsMANSFVGTRSY
D285	SFGRPVVDGADGEPH
S293	GADGEPHSVsPRPRP
S295-p	DGEPHSVsPRPRPPG
S306	RPPGRPISGHGMDSR
K361	PAERADLKLLTNHAF
S372	NHAFIKRSEGEDVDF
S393-p	TLRLKQPstPTRTAV
T394-p	LRLKQPstPTRTAV_
T396	LKQPstPTRTAV___
T398	QPstPTRTAV_____

	chicken
T13	KPVLPALTITPSPAE
G23	PSPAEGPGPGGSAEA
-	gap
K38	NLVDLQKKLEELELD
K49	LELDEQQKKRLEAFL
K59	LEAFLTQKAKVGELK
K61	AFLTQKAKVGELKDD
K66	KAKVGELKDDDFERI
S74	DDDFERISELGAGNG
K86	GNGGVVTKVQHKPSG
S92	TKVQHKPSGLIMARK
K99	SGLIMARKLIHLEIK
K106	KLIHLEIKPAIRNQI
K194	QIMHRDVKPSNILVN
K207	VNSRGEIKLCDFGVS
S214	KLCDFGVSGQLIDSM
S220	VSGQLIDSMANSFVG
S220	VSGQLIDSMANSFVG
S224	LIDSMANSFVGTRSY
S224	LIDSMANSFVGTRSY
D283	IFGRPVVDGAEGESH
S291	GAEGESHSVSPWARP
S293	EGESHSVSPWARPPG
S304	RPPGRPISGHGMDSR
K359	PAERADLKMLMNHTF
S370	NHTFIKRSEVEEVDF
S391	TLRLNQPSTPTRAAV
T392	LRLNQPSTPTRAAV_
T394	LNQPSTPTRAAV___
A396	QPSTPTRAAV_____

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