a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; EC 220.127.116.11; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: Golgi apparatus; peroxisomal membrane; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; cell cortex; intercellular junction; cytosol; perinuclear region of cytoplasm; cytoplasm; late endosome; nucleus
Molecular Function: nucleotide binding; PDZ domain binding; protein kinase activity; MAP kinase kinase activity; transferase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; protein complex scaffold; kinase activity; ATP binding
Biological Process: regulation of stress-activated MAPK cascade; activation of MAPK activity; MAPKKK cascade; phosphorylation; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.