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Protein Page:
MEK2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEK2 a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; STE group; STE7 family
Cellular Component: peroxisomal membrane; Golgi apparatus; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; cell cortex; intercellular junction; cytosol; perinuclear region of cytoplasm; cytoplasm; late endosome; nucleus
Molecular Function: nucleotide binding; protein kinase activity; PDZ domain binding; MAP kinase kinase activity; transferase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; protein complex scaffold; kinase activity; ATP binding
Biological Process: regulation of stress-activated MAPK cascade; activation of MAPK activity; MAPKKK cascade; protein amino acid phosphorylation; phosphorylation
Reference #:  Q63932 (UniProtKB)
Alt. Names/Synonyms: AA589381; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; MK2; Mkk2; MP2K2; OTTMUSP00000018442; Prkmk2; protein kinase, mitogen activated, kinase 2, p45
Gene Symbols: Map2k2
Molecular weight: 44,402 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 T13 KPVLPALTINPTIAE
0 9 S23-p PTIAEGPsPtsEGAs
0 1 T25-p IAEGPsPtsEGAsEA
0 2 S26-p AEGPsPtsEGAsEAN
0 1 S30-p sPtsEGAsEANLVDL
0 1 K40 NLVDLQKKLEELDLD
0 1 R51 LDLDEQQRKRLEAFL
0 1 K61 LEAFLTQKAKVGELK
0 1 K63 AFLTQKAKVGELKDD
0 2 K68 KAKVGELKDDDFERI
0 1 S76-p DDDFERIsELGAGNG
0 1 K88-ub GNGGVVTkARHRPSG
0 1 S94 TkARHRPSGLIMARK
0 9 K101 SGLIMARKLIHLEIK
0 12 K108 KLIHLEIKPAVRNQI
0 27 K196-ub QIMHRDVkPSNILVN
0 12 K209 VNSRGEIKLCDFGVs
2 4 S216-p KLCDFGVsGQLIDsM
41 77 S222-p VsGQLIDsMANsFVG
6 0 S222-ac VsGQLIDsMANsFVG
42 203 S226-p LIDsMANsFVGTRSY
2 0 S226-ac LIDsMANsFVGTRSY
0 1 D285 SFGRPVVDGADGEPH
0 4 S293-p GADGEPHsVsPRPRP
0 12 S295-p DGEPHsVsPRPRPPG
1 2 S306 RPPGRPISVGHGMDS
0 1 S313 SVGHGMDSRPAMAIF
0 1 K362-ub PAERADLkLLMNHAF
0 1 S373 NHAFIKRSEGEEVDF
0 6 S394-p TLRLKQPstPTRTAV
0 88 T395-p LRLKQPstPTRTAV_
1 16 T397 LKQPstPTRTAV___
1 0 T399 QPstPTRTAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
  human

 
T13-ac KPVLPALtINPTIAE
S23-p PTIAEGPsPtsEGAS
T25-p IAEGPsPtsEGASEA
S26-p AEGPsPtsEGASEAN
S30 sPtsEGASEANLVDL
K40-ub NLVDLQKkLEELELD
K51-ub LELDEQQkKRLEAFL
K61-ub LEAFLTQkAkVGELk
K63-ub AFLTQkAkVGELkDD
K68-ub kAkVGELkDDDFERI
S76 DDDFERISELGAGNG
K88 GNGGVVTKVQHRPsG
S94-p TKVQHRPsGLIMARk
K101-ub sGLIMARkLIHLEIk
K108-ub kLIHLEIkPAIRNQI
K196-ub QIMHRDVkPSNILVN
K209-ub VNSRGEIkLCDFGVs
S216-p kLCDFGVsGQLIDsM
S222-p VsGQLIDsMANsFVG
S222-ac VsGQLIDsMANsFVG
S226-p LIDsMANsFVGTRSY
S226-ac LIDsMANsFVGTRSY
D285-ca IFGRPVVdGEEGEPH
S293-p GEEGEPHsIsPRPRP
S295-p EGEPHsIsPRPRPPG
S306-p RPPGRPVsGHGMDsR
S312-p VsGHGMDsRPAMAIF
K361 PAERADLKMLTNHTF
S372-p NHTFIKRsEVEEVDF
G393 TLRLNQPGtPtRtAV
T394-p LRLNQPGtPtRtAV_
T396-p LNQPGtPtRtAV___
T398-p QPGtPtRtAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
  rat

 
T13 KPVLPALTINPTIAE
S23 PTIAEGPSPTSEGAS
T25 IAEGPSPTSEGASEA
S26 AEGPSPTSEGASEAH
S30 SPTSEGASEAHLVDL
K40 HLVDLQKKLEELDLD
R51 LDLDEQQRKRLEAFL
K61 LEAFLTQKAKVGELK
K63 AFLTQKAKVGELKDD
K68 KAKVGELKDDDFERI
S76 DDDFERISELGAGNG
K88 GNGGVVTKARHRPSG
S94 TKARHRPSGLIMARK
K101 SGLIMARKLIHLEIK
K108 KLIHLEIKPAVRNQI
K196-ub QIMHRDVkPSNILVN
K209 VNSRGEIKLCDFGVS
S216 KLCDFGVSGQLIDsM
S222-p VSGQLIDsMANsFVG
S222-ac VSGQLIDsMANsFVG
S226-p LIDsMANsFVGTRSY
S226 LIDsMANSFVGTRSY
D285 SFGRPVVDGADGEPH
S293 GADGEPHSVsPRPRP
S295-p DGEPHSVsPRPRPPG
S306 RPPGRPISGHGMDSR
S312 ISGHGMDSRPAMAIF
K361 PAERADLKLLTNHAF
S372 NHAFIKRSEGEDVDF
S393-p TLRLKQPstPTRTAV
T394-p LRLKQPstPTRTAV_
T396 LKQPstPTRTAV___
T398 QPstPTRTAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
  chicken

 
T13 KPVLPALTITPSPAE
G23 PSPAEGPGPGGSAEA
G25 PAEGPGPGGSAEANL
- gap
A28 GPGPGGSAEANLVDL
K38 NLVDLQKKLEELELD
K49 LELDEQQKKRLEAFL
K59 LEAFLTQKAKVGELK
K61 AFLTQKAKVGELKDD
K66 KAKVGELKDDDFERI
S74 DDDFERISELGAGNG
K86 GNGGVVTKVQHKPSG
S92 TKVQHKPSGLIMARK
K99 SGLIMARKLIHLEIK
K106 KLIHLEIKPAIRNQI
K194 QIMHRDVKPSNILVN
K207 VNSRGEIKLCDFGVS
S214 KLCDFGVSGQLIDSM
S220 VSGQLIDSMANSFVG
S220 VSGQLIDSMANSFVG
S224 LIDSMANSFVGTRSY
S224 LIDSMANSFVGTRSY
D283 IFGRPVVDGAEGESH
S291 GAEGESHSVSPWARP
S293 EGESHSVSPWARPPG
S304 RPPGRPISGHGMDSR
S310 ISGHGMDSRPAMAIF
K359 PAERADLKMLMNHTF
S370 NHTFIKRSEVEEVDF
S391 TLRLNQPSTPTRAAV
T392 LRLNQPSTPTRAAV_
T394 LNQPSTPTRAAV___
A396 QPSTPTRAAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
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