Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
OTX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
OTX2 Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: growth cone; protein complex; cytoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; eukaryotic initiation factor 4E binding
Biological Process: axon guidance; inner ear morphogenesis; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; regulation of fibroblast growth factor receptor signaling pathway; cell fate specification; somite rostral/caudal axis specification; metencephalon development; eye photoreceptor cell fate commitment; positive regulation of embryonic development; dorsal/ventral pattern formation; midbrain development; forebrain development; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; endoderm development; regulation of smoothened signaling pathway
Reference #:  P32243 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein OTX2; MCOPS5; MGC45000; orthodenticle homeobox 2; Orthodenticle homolog 2; OTX2
Gene Symbols: OTX2
Molecular weight: 31,636 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OTX2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T18-p AVNGLSLtTSGMDLL
0 1 S28-p GMDLLHPsVGyPATP
0 1 Y31-p LLHPsVGyPATPRKQ
0 1 K59 VLEALFAKTRYPDIF
0 1 T115 VRPAKKKTSPAREVS
0 2 K278 NADCLDYKDQTSSWK
  mouse

 
T18 AVNGLSLTTSGMDLL
S28 GMDLLHPSVGYPATP
Y31 LLHPSVGYPATPRKQ
K59-ub VLEALFAkTRYPDIF
S115-p VRPAKKKsSPAREVS
K278-ub NADCLDYkDQTSSWK
  rat

 
T18 AVNGLSLTTSGMDLL
S28 GMDLLHPSVGYPATP
Y31 LLHPSVGYPATPRKQ
K59 VLEALFAKTRYPDIF
T115 VRPAKKKTSPAREVS
K278 NADCLDYKDQTSSWK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.