Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component: protein complex; growth cone; cytoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; eukaryotic initiation factor 4E binding
Biological Process: axon guidance; inner ear morphogenesis; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; regulation of fibroblast growth factor receptor signaling pathway; cell fate specification; somite rostral/caudal axis specification; metencephalon development; positive regulation of embryonic development; eye photoreceptor cell fate commitment; dorsal/ventral pattern formation; midbrain development; forebrain development; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; endoderm development; regulation of smoothened signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.