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Protein Page:
OTX2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

OTX2 Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: protein complex; growth cone; cytoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; protein heterodimerization activity; eukaryotic initiation factor 4E binding
Biological Process: axon guidance; inner ear morphogenesis; positive regulation of transcription, DNA-dependent; regulation of fibroblast growth factor receptor signaling pathway; diencephalon morphogenesis; cell fate specification; somite rostral/caudal axis specification; metencephalon development; eye photoreceptor cell fate commitment; positive regulation of embryonic development; dorsal/ventral pattern formation; forebrain development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; regulation of smoothened signaling pathway; endoderm development
Reference #:  P32243 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein OTX2; MCOPS5; MGC45000; orthodenticle homeobox 2; Orthodenticle homolog 2; OTX2
Gene Symbols: OTX2
Molecular weight: 31,636 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

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SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.




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