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OTX2 (human)

Overview OTX2 Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: growth cone; protein complex; cytoplasm; nucleus Molecular Function: protein binding; sequence-specific DNA binding; protein heterodimerization activity; eukaryotic initiation factor 4E binding; transcription factor activity Biological Process: axon guidance; inner ear morphogenesis; positive regulation of transcription, DNA-dependent; regulation of fibroblast growth factor receptor signaling pathway; cell fate specification; somite rostral/caudal axis specification; eye photoreceptor cell fate commitment; positive regulation of embryonic development; dorsal/ventral pattern formation; regulation of transcription, DNA-dependent; midbrain development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; regulation of smoothened signaling pathway; endoderm development Reference #:  P32243 (UniProtKB) Alt. Names/Synonyms: Homeobox protein OTX2; MCOPS5; MGC45000; orthodenticle homeobox 2; Orthodenticle homolog 2; OTX2 Gene Symbols: OTX2 Molecular weight: 31,636 Da Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below OTX2 2DMS - A=39-105 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 600037 610125  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T18-p	AVNGLSLtTSGMDLL
0	1		S28-p	GMDLLHPsVGyPATP
0	1		Y31-p	LLHPsVGyPATPRKQ
0	1		K59	VLEALFAKTRYPDIF
0	1		T115	VRPAKKKTSPAREVS
0	2		K278	NADCLDYKDQTSSWK

	mouse
T18	AVNGLSLTTSGMDLL
S28	GMDLLHPSVGYPATP
Y31	LLHPSVGYPATPRKQ
K59-u	VLEALFAkTRYPDIF
S115-p	VRPAKKKsSPAREVS
K278-u	NADCLDYkDQTSSWK

	rat
T18	AVNGLSLTTSGMDLL
S28	GMDLLHPSVGYPATP
Y31	LLHPSVGYPATPRKQ
K59	VLEALFAKTRYPDIF
T115	VRPAKKKTSPAREVS
K278	NADCLDYKDQTSSWK

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