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Protein Page:
PPP2R2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPP2R2A The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Expressed in all tissues examined. Belongs to the phosphatase 2A regulatory subunit B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Cellular Component: nucleoplasm; protein phosphatase type 2A complex; cytosol
Molecular Function: protein binding; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity
Biological Process: mitotic nuclear envelope reassembly; RNA metabolic process; regulation of catalytic activity; mRNA catabolic process, nonsense-mediated decay; response to morphine; gene expression; mitotic cell cycle; protein amino acid dephosphorylation; signal transduction; G2/M transition of mitotic cell cycle; mRNA metabolic process
Reference #:  P63151 (UniProtKB)
Alt. Names/Synonyms: 2ABA; B55A; B55ALPHA; DKFZp686N05117; FLJ26613; FLJ41727; MGC52248; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PPP2R2A; PR52A; PR55A; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform; protein phosphatase 2, regulatory subunit B, alpha; serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
Gene Symbols: PPP2R2A
Molecular weight: 51,692 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2R2A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 14 K62-ub FQQEQENkIQSHSRG
0 2 K62-ac FQQEQENkIQSHSRG
0 1 K88-ac EPEFDYLkSLEIEEk
0 3 K88-ub EPEFDYLkSLEIEEk
0 1 K95-ub kSLEIEEkINkIRWL
0 1 K98-ac EIEEkINkIRWLPQk
0 6 K105-ub kIRWLPQkNAAQFLL
0 1 K117-ub FLLSTNDkTIKLWKI
0 7 K129-ub WKISERDkRPEGYNL
0 4 K137-ub RPEGYNLkEEDGRYR
0 4 S167-p MDLMVEAsPRRIFAN
0 2 K267-ub ALCDRHSkLFEEPED
0 1 S355-p CCWNGSDsVVMtGSY
0 1 T359-p GSDsVVMtGSYNNFF
0 2 T378-p RNTKRDItLEASREN
0 18 K402-ac RKVCASGkRkKDEIS
0 1 K404-ub VCASGkRkKDEISVD
0 1 Y440-p VATTNNLyIFQDKVN
  mouse

 
K62-ub FQQEQENkIQSHSRG
K62 FQQEQENKIQSHSRG
K88 EPEFDYLKSLEIEEK
K88 EPEFDYLKSLEIEEK
K95 KSLEIEEKINKIRWL
K98 EIEEKINKIRWLPQk
K105-ub KIRWLPQkNAAQFLL
K117 FLLSTNDKTIKLWKI
K129-ub WKISERDkRPEGYNL
K137 RPEGYNLKEEDGRYR
S167-p MDLMVEAsPRRIFAN
K267-ub ALCDRHSkLFEEPED
S355 CCWNGSDSVVMTGSY
T359 GSDSVVMTGSYNNFF
T378-p RNTKRDItLEASREN
K402-ac RKVCASGkRKKDEIS
K404 VCASGkRKKDEISVD
Y440 VATTNNLYIFQDKVN
  rat

 
K62 FQQEQENKIQSHSRG
K62 FQQEQENKIQSHSRG
K88 EPEFDYLKSLEIEEK
K88 EPEFDYLKSLEIEEK
K95 KSLEIEEKINKIRWL
K98 EIEEKINKIRWLPQK
K105 KIRWLPQKNAAQFLL
K117 FLLSTNDKTIKLWKI
K129 WKISERDKRPEGYNL
K137 RPEGYNLKEEDGRYR
S167 MDLMVEASPRRIFAN
K267 ALCDRHSKLFEEPED
S355 CCWNGSDSVVMTGSY
T359 GSDSVVMTGSYNNFF
T378 RNTKRDITLEASREN
K402 RKVCASGKRKKDEIS
K404 VCASGKRKKDEISVD
Y440 VATTNNLYIFQDKVN
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