The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Expressed in all tissues examined. Belongs to the phosphatase 2A regulatory subunit B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; protein phosphatase type 2A complex; cytosol
Molecular Function: protein binding; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity
Biological Process: mitotic nuclear envelope reassembly; RNA metabolic process; regulation of catalytic activity; mRNA catabolic process, nonsense-mediated decay; response to morphine; gene expression; mitotic cell cycle; protein amino acid dephosphorylation; G2/M transition of mitotic cell cycle; signal transduction; mRNA metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.