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Protein Page:
PPP2R1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPP2R1A The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Belongs to the phosphatase 2A regulatory subunit A family. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Cellular Component: microtubule cytoskeleton; protein phosphatase type 2A complex; mitochondrion; membrane; cytosol; nucleus; chromosome, pericentric region
Molecular Function: protein binding; protein heterodimerization activity; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity; antigen binding
Biological Process: mitotic nuclear envelope reassembly; apoptosis; protein amino acid dephosphorylation; chromosome segregation; response to organic substance; regulation of transcription, DNA-dependent; RNA metabolic process; regulation of cell differentiation; regulation of growth; protein complex assembly; G2/M transition of mitotic cell cycle; inactivation of MAPK activity; regulation of DNA replication; regulation of cell adhesion; second-messenger-mediated signaling; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; mRNA metabolic process; mRNA catabolic process, nonsense-mediated decay; negative regulation of tyrosine phosphorylation of Stat3 protein; gene expression; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process
Reference #:  P30153 (UniProtKB)
Alt. Names/Synonyms: 2AAA; Medium tumor antigen-associated 61 kDa protein; MGC786; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2A-Aalpha; PP2AAALPHA; PPP2R1A; PR65A; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2, regulatory subunit A, alpha; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Gene Symbols: PPP2R1A
Molecular weight: 65,309 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2R1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p AAADGDDsLYPIAVL
0 2 K34-ub LRLNSIKkLSTIALA
0 1 S36 LNSIKkLSTIALALG
0 34 K107-ub EETVVRDkAVESLRA
0 2 K133-ub AHFVPLVkRLAGGDW
0 40 K163-ub PRVSSAVkAELRQYF
0 136 K188-ub VRRAAASkLGEFAkV
0 17 K194-ub SkLGEFAkVLELDNV
0 1 K202-ub VLELDNVkSEIIPMF
0 97 K266-ub VRYMVADkFTELQkA
1 1 T268 YMVADkFTELQkAVG
0 4 K272-ub DkFTELQkAVGPEIT
0 5 K280-ac AVGPEITkTDLVPAF
0 4 K280-ub AVGPEITkTDLVPAF
1 1 S303 AEVRAAASHkVkEFC
0 1 K305-ub VRAAASHkVkEFCEN
0 6 K307-ub AAASHkVkEFCENLS
1 1 S314 kEFCENLSADCRENV
0 2 S335-p PCIKELVsDANQHVK
0 2 S343-p DANQHVKsALASVIM
0 12 K374-ub PLFLAQLkDECPEVR
0 12 K416-ub VELAEDAkWRVRLAI
0 1 K467-ub EAATSNLkKLVEkFG
0 1 K467-sc EAATSNLkKLVEkFG
0 1 K472-ub NLkKLVEkFGkEWAH
0 2 K475-ub KLVEkFGkEWAHATI
0 1 K485-ub AHATIIPkVLAMSGD
0 9 K519-ub CGQDITTkHMLPTVL
0 4 K542-ub NVRFNVAkSLQkIGP
0 28 K546-ub NVAkSLQkIGPILDN
0 1 S554-p IGPILDNsTLQSEVk
0 1 K561-ac sTLQSEVkPILEkLT
0 12 K561-ub sTLQSEVkPILEkLT
0 4 K566-ub EVkPILEkLTQDQDV
0 1 T584-p YFAQEALtVLSLA__
  mouse

 
S9 AAADGDDSLYPIAVL
K34-ub LRLNSIKkLSTIALA
S36 LNSIKkLSTIALALG
K107-ub EETVVRDkAVESLRA
K133 AHFVPLVKRLAGGDW
K163-ub PRVSSAVkAELRQYF
K188-ub VRRAAASkLGEFAKV
K194 SkLGEFAKVLELDNV
K202 VLELDNVKSEIIPMF
K266-ub VRYMVADkFTELQkA
T268 YMVADkFTELQkAVG
K272-ub DkFTELQkAVGPEIT
K280-ac AVGPEITkTDLVPAF
K280-ub AVGPEITkTDLVPAF
S303 AEVRAAASHKVkEFC
K305 VRAAASHKVkEFCEN
K307-ub AAASHKVkEFCENLS
S314 kEFCENLSADCRENV
S335 PCIKELVSDANQHVK
S343 DANQHVKSALASVIM
K374-ub PLFLAQLkDECPEVR
K416-ub VELAEDAkWRVRLAI
K467 EAATSNLKKLVEKFG
K467 EAATSNLKKLVEKFG
K472 NLKKLVEKFGKEWAH
K475 KLVEKFGKEWAHATI
K485 AHATIIPKVLAMSGD
K519 CGQDITTKHMLPTVL
K542 NVRFNVAKSLQkIGP
K546-ub NVAKSLQkIGPILDN
S554 IGPILDNSTLQSEVk
K561 STLQSEVKPILEKLT
K561-ub STLQSEVkPILEKLT
K566 EVkPILEKLTQDQDV
T584 YFAQEALTVLSLA__
  rat

 
S9 AAADGDDSLYPIAVL
K34 LRLNSIKKLsTIALA
S36-p LNSIKKLsTIALALG
K107 EETVVRDKAVESLRA
K133 AHFVPLVKRLAGGDW
K163-ub PRVSSAVkAELRQYF
K188-ub VRRAAASkLGEFAKV
K194 SkLGEFAKVLELDNV
K202 VLELDNVKSEIIPMF
K266-ub VRYMVADkFtELQKA
T268-p YMVADkFtELQKAVG
K272 DkFtELQKAVGPEIT
K280-ac AVGPEITkTDLVPAF
K280 AVGPEITKTDLVPAF
S303-p AEVRAAAsHKVKEFC
K305 VRAAAsHKVKEFCEN
K307 AAAsHKVKEFCENLs
S314-p KEFCENLsADCRENV
S335 PCIKELVSDANQHVK
S343 DANQHVKSALASVIM
K374 PLFLAQLKDECPEVR
K416 VELAEDAKWRVRLAI
K467 EAATSNLKKLVEKFG
K467 EAATSNLKKLVEKFG
K472 NLKKLVEKFGKEWAH
K475 KLVEKFGKEWAHATI
K485 AHATIIPKVLAMSGD
K519 CGQDITTKHMLPTVL
K542 NVRFNVAKSLQKIGP
K546 NVAKSLQKIGPILDN
S554 IGPILDNSTLQSEVk
K561-ac STLQSEVkPILEkLT
K561-ub STLQSEVkPILEkLT
K566-ub EVkPILEkLTQDQDV
T584 YFAQEALTVLSLA__
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