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Protein Page:
CBP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts via its N-terminus with the C-terminus of SS18L1. Interacts with MECOM. Chromosomal aberrations involving CBP may be a cause of acute myeloid leukemias. Known translocation partners include MYST3, MLL, and MYST4. MYST3-CBP fusion proteins may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1), an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; DNA binding protein; EC 2.3.1.48; Acetyltransferase; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; nuclear body; transcription factor complex; cytoplasm; nuclear chromatin; nucleolus; outer kinetochore of condensed chromosome; nucleus; histone acetyltransferase complex
Molecular Function: signal transducer activity; protein binding; MRF binding; histone acetyltransferase activity; zinc ion binding; p53 binding; acetyltransferase activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription factor binding
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; viral reproduction; positive regulation of transcription, DNA-dependent; rhythmic process; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; signal transduction; homeostatic process; regulation of transcription, DNA-dependent; response to hypoxia; positive regulation of interferon type I production; innate immune response; gene expression; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; embryonic digit morphogenesis; histone acetylation; N-terminal peptidyl-lysine acetylation; regulation of smoothened signaling pathway
Reference #:  Q92793 (UniProtKB)
Alt. Names/Synonyms: CBP; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; RSTS
Gene Symbols: CREBBP
Molecular weight: 265,351 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Crosstalk between PTMs  |  NF-kB Signaling  |  Protein Acetylation  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CBP

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y659‑p
molecular association, regulation: Y659‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K13-ac LDGPPNPkRAKLSSP
1 0 S78-p SELLRGGsGSSINPG
1 0 S93-p IGNVSASsPVQQGLG
0 12 S121-p SLSAMGKsPLsQGDS
0 16 S124-p AMGKsPLsQGDSsAP
0 1 S129-p PLsQGDSsAPSLPKQ
0 1 S148 SGPTPAASQALNPQA
0 1 R220-m1 LGAAGRGrGAGMPYP
0 2 S274-p MGITGNTsPFGQPFS
1 0 S302 PQLASKQSMVNSLPT
0 1 T320-p DIKNTSVtNVPNMSQ
0 1 K366-ac VLLLHAHkCQRREQA
0 1 K389-ac LPHCRTMkNVLNHMT
4 0 S437-p CLPLKNAsDKRNQQT
0 1 S469 TGQQNATSLSNPNPI
0 1 S471 QQNATSLSNPNPIDP
2 0 R601-me EHVTQDLrSHLVHKL
0 2 K622-ac TPDPAALkDRRMENL
1 0 R624 DPAALkDRRMENLVA
1 0 R625 PAALkDRRMENLVAY
0 1 Y641 KKVEGDMYESANSRD
0 1 K657-ac YYHLLAEkIyKIQKE
1 1 Y659-p HLLAEkIyKIQKELE
1 0 R714-me PLSLPVNrMQVSQGM
1 0 R742-me PQAPMGPrAASPMNH
1 0 R768-me GMAISPSrMPQPPNM
1 0 K998 DVPVLEMKTEtQAED
0 2 T1001-p VLEMKTEtQAEDTEP
0 1 A1003 EMKTEtQAEDTEPDP
0 9 K1014-ac EPDPGESkGEPRSEM
0 3 S1030-p EEDLQGAsQVKEETD
1 0 K1033 LQGAsQVKEETDIAE
0 1 K1042-ac ETDIAEQkSEPMEVD
1 0 K1056 DEKKPEVKVEVKEEE
0 1 S1072-p SSSNGTAsQSTsPSQ
0 3 S1076-p GTAsQSTsPSQPRKK
0 1 T1171-p AWLYNRKtSRVYKFC
0 1 K1203-ac LGYCCGRkYEFSPQT
0 70 K1216-ac QTLCCYGkQLCTIPR
0 1 K1367-ac RVVASSDkTVEVKPG
0 1 K1372 SDkTVEVKPGMkSRF
0 1 K1376-ac VEVKPGMkSRFVDsG
1 0 S1382-p MkSRFVDsGEMsESF
1 0 S1386-p FVDsGEMsESFPyRT
0 5 Y1391-p EMsESFPyRTKALFA
0 2 Y1450-p RCLRTAVyHEILIGy
0 2 Y1457-p yHEILIGyLEyVKKL
0 2 Y1460-p ILIGyLEyVKKLGYV
0 10 K1535-ac EDRLTSAkELPYFEG
0 3 K1564-ac EQEEEERkkEEstAA
0 1 K1565-m1 QEEEERkkEEstAAS
0 1 S1568-p EERkkEEstAASETT
0 1 T1569-p ERkkEEstAASETTE
0 8 S1578-p ASETTEGsQGDSkNA
0 214 K1583-ac EGsQGDSkNAkkkNN
0 213 K1586-ac QGDSkNAkkkNNkkT
0 156 K1587-ac GDSkNAkkkNNkkTN
0 70 K1588-ac DSkNAkkkNNkkTNk
0 230 K1591-ac NAkkkNNkkTNkNkS
0 244 K1592-ac AkkkNNkkTNkNkSS
0 244 K1595-ac kNNkkTNkNkSSISR
0 140 K1597-ac NkkTNkNkSSISRAN
0 8 K1620-ac VSNDLSQkLyATMEk
0 1 Y1622-p NDLSQkLyATMEkHK
0 6 K1627-ac kLyATMEkHKEVFFV
0 1 T1697-p CMLVELHtQGQDRFV
0 11 K1711-ac VYTCNECkHHVETRW
0 6 K1736-ac CINCYNTkSHAHkMV
0 27 K1741-ac NTkSHAHkMVkWGLG
0 25 K1744-ac SHAHkMVkWGLGLDD
0 1 S1754-p LGLDDEGssQGEPQS
0 2 S1755-p GLDDEGssQGEPQSk
0 3 K1762-ac sQGEPQSksPQESRR
0 2 S1763-p QGEPQSksPQESRRL
0 16 K1797-ac CSLPSCQkMkRVVQH
0 5 K1799-ac LPSCQkMkRVVQHTk
0 12 K1806-ac kRVVQHTkGCkRKTN
0 12 K1809-ac VQHTkGCkRKTNGGC
0 6 K1837-ac AKHCQENkCPVPFCL
1 0 T1871-p LMRRRMAtMNtRNVP
0 1 T1874-p RRMAtMNtRNVPQQS
0 1 K1937-ac PTTVSTGkPTSQVPA
0 1 Y1973-p AQQQQHLyRVNINNS
1 0 P2014 QVSGPVMPSMPPGQW
0 1 S2041-p GLPRPVIsMQAQAAV
0 12 S2063-p VQPPRSIsPsALQDL
0 1 S2065-p PPRSIsPsALQDLLR
0 1 T2073-p ALQDLLRtLKsPSsP
0 1 S2076-p DLLRtLKsPSsPQQQ
0 4 S2079-p RtLKsPSsPQQQQQV
0 1 K2102-ub QLMAAFIkQRTAKYV
0 3 S2351-p RSPAPVQsPRPQsQP
0 1 S2356-p VQsPRPQsQPPHSSP
0 2 S2361 PQsQPPHSSPsPRIQ
0 1 S2361 PQsQPPHSSPsPRIQ
0 2 S2364-p QPPHSSPsPRIQPQP
0 1 S2406-p HLGNPEQsAMLPQLN
0 1 S2422-p PSRSALSsELsLVGD
0 1 S2425-p SALSsELsLVGDTTG
4771 : Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody
  mouse

 
K13 LDGPPNPKRAKLSSP
S77 SELLRGGSGSSINPG
S92 IGNVSASSPVQQGLG
S120-p SLGAMGKsPLNQGDS
N123 AMGKsPLNQGDSSTP
S128 PLNQGDSSTPNLPKQ
S147-gl SGPTPPAsQALNPQA
R219 LGAAGRGRGAGMPYP
S273-p MGMTGTTsPFGQPFS
S301-p PQLASKQsMVNSLPA
T319 DIKNTSVTTVPNMSQ
K365 VLLLHAHKCQRREQA
K388 LPHCRTMKNVLNHMT
S436-p CLPLKNAsDKRNQQT
S468-p AGQQNATsLsNPNPI
S470-p QQNATsLsNPNPIDP
R600-me EHVTQDLrSHLVHKL
K621 TPDPAALKDrrMENL
R623-me DPAALKDrrMENLVA
R624-me PAALKDrrMENLVAY
Y640 KKVEGDMYESANSRD
K656 YYHLLAEKIYKIQKE
Y658 HLLAEKIYKIQKELE
R713 PLPLPVNRMQVSQGM
R741 PQAPMGPRAASPMNH
R767 GMAISPSRMPQPPNM
K999-sm DVPMLEMkTEVQtDD
V1002 MLEMkTEVQtDDAEP
T1004-p EMkTEVQtDDAEPEP
K1015-ac EPEPTESkGEPRSEM
S1031 EEDLQGSSQVkEETD
K1034-sm LQGSSQVkEETDTTE
K1043 ETDTTEQKSEPMEVE
K1057-sm EEKKPEVkVEAKEEE
S1073 NSSNDTASQSTsPSQ
S1077-p DTASQSTsPSQPRKK
T1172 AWLYNRKTSRVYKFC
K1204 LGYCCGRKYEFSPQT
K1217 QTLCCYGKQLCTIPR
K1368 RVVASSDKTVEVkPG
K1373-ac SDKTVEVkPGMKSRF
K1377 VEVkPGMKSRFVDSG
S1383 MKSRFVDSGEMSESF
S1387 FVDSGEMSESFPYRT
Y1392 EMSESFPYRTKALFA
Y1451-p RCLRTAVyHEILIGy
Y1458-p yHEILIGyLEyVKKL
Y1461-p ILIGyLEyVKKLGYV
K1536-ac EDRLTSAkELPYFEG
K1565 EQEEEERKKEESTAA
K1566 QEEEERKKEESTAAS
S1569 EERKKEESTAASETP
T1570 ERKKEESTAASETPE
S1579 ASETPEGSQGDSkNA
K1584-ac EGSQGDSkNAkkkNN
K1587-ac QGDSkNAkkkNNkkT
K1588-ac GDSkNAkkkNNkkTN
K1589-ac DSkNAkkkNNkkTNk
K1592-ac NAkkkNNkkTNkNkS
K1593-ac AkkkNNkkTNkNkSS
K1596-ac kNNkkTNkNkSSISR
K1598-ac NkkTNkNkSSISRAN
K1621 VSNDLSQKLYATMEk
Y1623 NDLSQKLYATMEkHK
K1628-ac KLYATMEkHKEVFFV
T1698 CMLVELHTQGQDRFV
K1712 VYTCNECKHHVETRW
K1737 CINCYNTKSHTHkMV
K1742-ac NTKSHTHkMVkWGLG
K1745-ac SHTHkMVkWGLGLDD
S1755 LGLDDEGSSQGEPQS
S1756 GLDDEGSSQGEPQSk
K1763-ac SQGEPQSksPQESRR
S1764-p QGEPQSksPQESRRL
K1798-ac CSLPSCQkMKRVVQH
K1800 LPSCQkMKRVVQHTK
K1807 KRVVQHTKGCKRKTN
K1810 VQHTKGCKRKTNGGC
K1838 AKHCQENKCPVPFCL
T1872-p LMRRRMAtMNTRNVP
T1875 RRMAtMNTRNVPQQS
K1938 PTIVSAGKPTNQVPA
Y1974 AQQQQHLYRANINNG
S2015-p QVSGPVMsSMPPGQW
S2042 GMPRPVMSMQAQAAV
S2064-p VQPPRSIsPSALQDL
S2066 PPRSIsPSALQDLLR
T2074 ALQDLLRTLKSPSSP
S2077 DLLRTLKSPSSPQQQ
S2080 RTLKSPSSPQQQQQV
K2103 QLMAAFIKQRTAKYV
S2350-p RSPAPVQsPRPQsQP
S2355-p VQsPRPQsQPPHsSP
S2360-p PQsQPPHsSPsPRIQ
S2360-gl PQsQPPHsSPsPRIQ
S2363-p QPPHsSPsPRIQPQP
S2405 HLGNPEQSAMLPQLN
S2421 PNRSALSSELSLVGD
S2424 SALSSELSLVGDTTG
4771 : Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody
  rat

 
K13 LDGPPNPKRAKLSSP
S77 SELLRGGSGSSITPG
S92 IGNVSASSPVQQGLG
S120 SLGAMGKSPLNPGDS
N123 AMGKSPLNPGDSSTP
S128 PLNPGDSSTPSLPKQ
S147 SGPTPPASQALNPQA
R219 LGAAGRGRGAGMPYP
S273 MGMTGNTSPFGQPFS
S301-p PQLASKQsMVNSLPA
T319 DIKNTSVTTVPNMSQ
K365 VLLLHAHKCQRREQA
K388 LPHCRTMKNVLNHMT
S436 CLPLKNASDKRNQQT
S468 AGQQNATSLSNPNPI
S470 QQNATSLSNPNPIDP
R600 EHVTQDLRSHLVHKL
K621 TPDPAALKDRRMENL
R623 DPAALKDRRMENLVA
R624 PAALKDRRMENLVAY
Y640-p KKVEGDMyESANSRD
K656 YYHLLAEKIYKIQKE
Y658 HLLAEKIYKIQKELE
R713 PLSLPVNRVQVSQGM
R741 PQAPMGPRAASPMNH
R767 GMAISPSRMPQPPNM
K999 DVPMLEMKTEVQTDD
V1002 MLEMKTEVQTDDAEP
T1004 EMKTEVQTDDAEPDP
K1015 EPDPAESKGEPRSEM
S1031 EEDLQGSSQVKEETD
K1034 LQGSSQVKEETDTTE
K1043 ETDTTEQKSEPMEVE
K1057 EEKKPEVKVEAKEEE
S1073 NSANGTASQSTsPSQ
S1077-p GTASQSTsPSQPRKK
T1172 AWLYNRKTSRVYKFC
K1204 LGYCCGRKYEFSPQT
K1217 QTLCCYGKQLCTIPR
K1368 RVVASSDKTVEVKPG
K1373 SDKTVEVKPGMKSRF
K1377 VEVKPGMKSRFVDSG
S1383 MKSRFVDSGEMSESF
S1387 FVDSGEMSESFPYRT
Y1392 EMSESFPYRTKALFA
Y1451 RCLRTAVYHEILIGY
Y1458 YHEILIGYLEYVKKL
Y1461 ILIGYLEYVKKLGYV
K1536 EDRLTSAKELPYFEG
K1565 EQEEEERKKEESTAA
K1566 QEEEERKKEESTAAS
S1569 EERKKEESTAASETP
T1570 ERKKEESTAASETPE
S1579 ASETPEGSQGDSKNA
K1584 EGSQGDSKNAKKKNN
K1587 QGDSKNAKKKNNKKT
K1588 GDSKNAKKKNNKKTN
K1589 DSKNAKKKNNKKTNK
K1592 NAKKKNNKKTNKNKS
K1593 AKKKNNKKTNKNKSS
K1596 KNNKKTNKNKSSISR
K1598 NKKTNKNKSSISRAN
K1621 VSNDLSQKLYATMEK
Y1623 NDLSQKLYATMEKHK
K1628 KLYATMEKHKEVFFV
T1698 CMLVELHTQGQDRFV
K1712 VYTCNECKHHVETRW
K1737 CINCYNTKSHTHKMV
K1742 NTKSHTHKMVKWGLG
K1745 SHTHKMVKWGLGLDD
S1755 LGLDDEGSSQGEPQS
S1756 GLDDEGSSQGEPQSK
K1763 SQGEPQSKSPQESRR
S1764 QGEPQSKSPQESRRL
K1798 CSLPSCQKMKRVVQH
K1800 LPSCQKMKRVVQHTK
K1807 KRVVQHTKGCKRKTN
K1810 VQHTKGCKRKTNGGC
K1838 AKHCQENKCPVPFCL
T1872 LMRRRMATMNTRNVP
T1875 RRMATMNTRNVPQQS
K1938 PTIVSAGKPTNQVPA
Y1974 GQQQQHLYRANINNG
S2015 QVSGPVMSSMPPGQW
S2042 GMPRPVMSMQAQAAV
S2064-p VQPPRSIsPSALQDL
S2066 PPRSIsPSALQDLLR
T2074 ALQDLLRTLKSPSSP
S2077 DLLRTLKSPSSPQQQ
S2080 RTLKSPSSPQQQQQV
K2103 QLMAAFIKQRTAKYV
S2351 RSPAPVQSPRPQSQP
S2356 VQSPRPQSQPPHSSP
S2361 PQSQPPHSSPSPRIQ
S2361 PQSQPPHSSPSPRIQ
S2364 QPPHSSPSPRIQPQP
S2406 HLGNPEQSAMLPQLN
S2422 PNRSALSSELSLVGD
S2425 SALSSELSLVGDTTG
4771 : Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody
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