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Protein Page:
Cbl (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Cbl an adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Participates in signal transduction in hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Motility/polarity/chemotaxis; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Adaptor/scaffold
Cellular Component: cytoplasm; plasma membrane; flotillin complex; cytosol; nucleus
Molecular Function: protein binding; signal transducer activity; ephrin receptor binding; phosphotyrosine binding; zinc ion binding; ubiquitin-protein ligase activity; calcium ion binding; transcription factor activity; SH3 domain binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; protein ubiquitination; positive regulation of receptor-mediated endocytosis; negative regulation of apoptosis
Reference #:  P22681 (UniProtKB)
Alt. Names/Synonyms: C-CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; CBL; CBL2; E3 ubiquitin-protein ligase CBL; oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RNF55; Signal transduction protein CBL
Gene Symbols: CBL
Molecular weight: 99,633 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Cbl

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y371‑p
cell cycle regulation: Y371‑p
cell growth, altered: Y371‑p, Y700‑p, Y731‑p, Y774‑p
cell motility, altered: Y674‑p, Y700‑p, Y731‑p, Y774‑p
activity, induced: Y731‑p
molecular association, regulation: Y371‑p, S619‑p, S623‑p, S639‑p, S642‑p, Y700‑p, Y731‑p, Y774‑p
phosphorylation: Y731‑p, Y774‑p
protein degradation: Y371‑p, Y700‑p, Y731‑p, Y774‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 K7-u _MAGNVKkSSGAGGG
0 1 S17-p GAGGGSGsGGSGSGG
0 1 T126-p MENLMKKtKQTISLF
0 2 K134-a KQTISLFkEGKERMy
0 16 Y141-p kEGKERMyEENSQPR
0 1 K197-a WRKAFGEkTIVPWkS
0 6 K203-u EkTIVPWkSFRQALH
1 5 Y368-p IKVTQEQyELyCEMG
5 77 Y371-p TQEQyELyCEMGSTF
0 6 K424-u PFCRCEIkGTEPIVV
0 2 S439-p DPFDPRGsGsLLRQG
0 2 S441-p FDPRGsGsLLRQGAE
0 4 S452-p QGAEGAPsPNyDDDD
0 31 Y455-p EGAPsPNyDDDDDER
0 2 P482 GAKVERPPsPFsMAP
0 12 S483-p AKVERPPsPFsMAPQ
0 9 S486-p ERPPsPFsMAPQASL
0 3 R506 RLDLLPQRVCVPSSA
0 4 Y552-p PPPPDRPySVGAESR
0 6 T568-p QRRPLPCtPGDCPSR
0 2 S601-p PIPKVPVsAPSSSDP
1 19 S619-p RELTNRHsLPFsLPS
1 3 S623-p NRHsLPFsLPSQMEP
1 2 S639-p PDVPRLGsTFsLDTs
1 8 S642-p PRLGsTFsLDTsMSM
0 3 S646-p sTFsLDTsMSMNSSP
0 26 S667-p DHPKIKPsssANAIy
0 16 S668-p HPKIKPsssANAIys
0 209 S669-p PKIKPsssANAIysL
2 716 Y674-p sssANAIysLAARPL
0 104 S675-p ssANAIysLAARPLP
0 5 G694 PPGEQCEGEEDtEyM
0 23 T698-p QCEGEEDtEyMtPss
9 497 Y700-p EGEEDtEyMtPssRP
0 11 T702-p EEDtEyMtPssRPLR
0 34 S704-p DtEyMtPssRPLRPL
0 22 S705-p tEyMtPssRPLRPLD
0 3 S716-p RPLDTSQssRACDCD
0 4 S717-p PLDTSQssRACDCDQ
12 34 Y731-p QQIDSCTyEAMyNIQ
0 5 Y735-p SCTyEAMyNIQSQAP
0 3 T762-p LAAAHANtGPEEsEN
0 236 S767-p ANtGPEEsENEDDGy
11 250 Y774-p sENEDDGyDVPKPPV
0 5 T789-p PAVLARRtLsDIsNA
0 31 S791-p VLARRtLsDIsNAss
0 1 S794-p RRtLsDIsNAsssFG
0 2 S797-p LsDIsNAsssFGWLs
0 1 S798-p sDIsNAsssFGWLsL
0 5 S799-p DIsNAsssFGWLsLD
0 14 S804-p sssFGWLsLDGDPTT
0 2 S833-p PFPRRINsERKAGSC
0 30 C840 sERKAGSCQQGSGPA
0 2 S900-p REFVSISsPAHVAT_
8869 : Phospho-c-Cbl (Tyr700) (D16D7) Rabbit mAb
3554 : Phospho-c-Cbl (Tyr731) Antibody
3555 : Phospho-c-Cbl (Tyr774) Antibody
  mouse

 
K7 _MAGNVKKSSGAGGG
S16 SGAGGGGSGGSGAGG
T124 MENLMKKTKQTISLF
K132 KQTISLFKEGKERMY
Y139 KEGKERMYEENSQPR
K195 WRKAFGEKTIVPWkS
K201-u EKTIVPWkSFRQALH
Y366 IKVTQEQYELYCEMG
Y369 TQEQYELYCEMGSTF
K422 PFCRCEIKGTEPIVV
S437 DPFDPRGSGsLLRQG
S439-p FDPRGSGsLLRQGAE
S450-p QGAEGAPsPNyDDDD
Y453-p EGAPsPNyDDDDDER
S480-p GAKVERPssPFsMAP
S481-p AKVERPssPFsMAPQ
S484-p ERPssPFsMAPQASL
R504 RLDLLQQRAPVPAST
Y550 PPPPDRPYSVGAETR
T566 QRRPLPCTPGDCPSR
A599 PIPKVPVATPNPGDP
S617-p RELTNRHsLPFSLPS
S621 NRHsLPFSLPSQMEP
S637-p ADVPRLGsTFsLDTS
S640-p PRLGsTFsLDTSMTM
S644 sTFsLDTSMTMNSSP
S665 EHPKIKPSssANAIy
S666-p HPKIKPSssANAIys
S667-p PKIKPSssANAIysL
Y672-p SssANAIysLAARPL
S673-p ssANAIysLAARPLP
S692-p PPGEQGEsEEDtEyM
T696-p QGEsEEDtEyMTPTs
Y698-p EsEEDtEyMTPTsRP
T700 EEDtEyMTPTsRPVG
T702 DtEyMTPTsRPVGVQ
S703-p tEyMTPTsRPVGVQK
S722 RPLEATQSSRACDCD
S723 PLEATQSSRACDCDQ
Y737-p QQIDSCTyEAMYNIQ
Y741 SCTyEAMYNIQSQAL
T768 LATAHTSTGPEEsEN
S773-p TSTGPEEsENEDDGy
Y780-p sENEDDGyDVPKPPV
T795-p PAVLARRtLsDISNA
S797-p VLARRtLsDISNAss
S800 RRtLsDISNAsssFG
S803-p LsDISNAsssFGWLs
S804-p sDISNAsssFGWLsL
S805-p DISNAsssFGWLsLD
S810-p sssFGWLsLDGDPTN
S838 PFPRRINSERKASSy
Y845-p SERKASSyQQGGGAT
S907 REFVSISSPAHVAT_
3555 : Phospho-c-Cbl (Tyr774) Antibody
  rat

 
K7 _MAGNVKKSSGAGGS
S16 SGAGGSGSGGSGAGG
T125 MENLMKKTKQTISLF
K133 KQTISLFKEGKERMY
Y140 KEGKERMYEENSQPR
K196 WRKAFGEKTIVPWKS
K202 EKTIVPWKSFRQALH
Y367 IKVTQEQYELYCEMG
Y370 TQEQYELYCEMGSTF
K423 PFCRCEIKGTEPIVV
S438 DPFDPRGSGSLLRQG
S440 FDPRGSGSLLRQGAE
S451 QGAEGAPSPNYDDDD
Y454 EGAPSPNYDDDDDER
S481 GAKVERPSSPFSMAP
S482 AKVERPSSPFSMAPQ
S485 ERPSSPFSMAPQASL
R505-m1 RLDLLQQrAPVPAST
Y551 PPPPDRPYSVGTETR
T567 QRRPLPCTPGDCPSR
A600 PIPKVPVATPNPGDP
S618 RELTNRHSLPFSLPS
S622 NRHSLPFSLPSQMEP
S638 ADVPRLGSTFSLDTS
S641 PRLGSTFSLDTSTTM
S645 STFSLDTSTTMNSSP
S666 EHPKIKPSSSANAIy
S667 HPKIKPSSSANAIyS
S668 PKIKPSSSANAIySL
Y673-p SSSANAIySLAARPL
S674 SSANAIySLAARPLP
S693 PPGEQGDSEEDTEyM
T697 QGDSEEDTEyMTPTS
Y699-p DSEEDTEyMTPTSRP
T701 EEDTEyMTPTSRPVG
T703 DTEyMTPTSRPVGVQ
S704 TEyMTPTSRPVGVQK
S723 RPAETAQSSRACDCD
S724 PAETAQSSRACDCDQ
Y738 QQIDSCTYEAMYNIQ
Y742 SCTYEAMYNIQSQAL
T769 LATAHTSTGPEESEN
S774 TSTGPEESENEDDGY
Y781 SENEDDGYDVPKPPV
T796 PAVLARRTLSDISNA
S798 VLARRTLSDISNASS
S801 RRTLSDISNASSSFG
S804 LSDISNASSSFGWLS
S805 SDISNASSSFGWLSL
S806 DISNASSSFGWLSLD
S811 SSSFGWLSLDGEPTN
S839 PFPRRINSERKASSY
Y846 SERKASSYQQGGGAM
S908 REFVSISSPAHVAT_
8869 : Phospho-c-Cbl (Tyr700) (D16D7) Rabbit mAb
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