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Casp9 (mouse)

Overview Casp9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.62; Protease; Apoptosis Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus; apoptosome Molecular Function: peptidase activity; protein binding; hydrolase activity; peptide binding; cysteine-type peptidase activity Biological Process: caspase activation; positive regulation of apoptosis; apoptosis; metabolic process; positive regulation of neuron apoptosis; induction of apoptosis; proteolysis; response to DNA damage stimulus; response to organic cyclic substance; response to UV Reference #:  Q9R0T0 (UniProtKB) Alt. Names/Synonyms: AI115399; AW493809; Casp9; caspase 9; Caspase-9; Caspase9; ICE-LAP6; Mch6; OTTMUSP00000010525 Gene Symbols: Casp9 Molecular weight: 50,051 Da Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Apoptosis  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp9 1JXQ - A/B/C/D=140-416 (human) 1NW9 - B=140-416 (human) 2AR9 - A/B/C/D=140-416 (human) 3D9T - D/C=316-321 (human) 3V3K - A/O/M/C/K/I/G/E=141-416 (human) 3YGS - P=1-95 (human)

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	Sites Implicated In
apoptosis, altered: T163‑p apoptosis, inhibited: S348‑p enzymatic activity, inhibited: T163‑p protein processing: S348‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		S132	RVVKLEPSQPAVGNL
6	5		T163-p	PEVLRPEtPRPVDIG
1	0		K182	HDVCVPGKIRGHADM
1	0		Y191	RGHADMAYTLDSDPC
0	1		S213	NVNFCPSSGLGTRTG
1	0		S221	GLGTRTGSNLDRDKL
1	0		R233	DKLEHRFRWLRFMVE
2	1		W234	KLEHRFRWLRFMVEV
0	1		S340	GFEVACTSSQGRTLD
0	2		T345	CTSSQGRTLDsDSEP
1	1		S348-p	SQGRTLDsDSEPDAV

	human
S99-p	NRQAAKLsKPTLENL
T125-p	PEVLRPEtPRPVDIG
S144-p	GDVGALEsLRGNADL
Y153-p	RGNADLAyILSMEPC
S175-p	NVNFCREsGLRTRTG
S183-p	GLRTRTGsNIDCEKL
S195-p	EKLRRRFssLHFMVE
S196-p	KLRRRFssLHFMVEV
S302-p	GFEVASTsPEDEsPG
S307-p	STsPEDEsPGsNPEP
S310-p	PEDEsPGsNPEPDAT

	rat
S132	KVVKLDPSQPALGNL
T163	PEVLTPETPRPVDIG
K182	HDVCTPGKIERHADM
Y191	ERHADMAYTLDSDPC
S213	NVNFCPSSGLSTRIG
S221	GLSTRIGSHVDCEKL
C233	EKLQHRFCWLRFMVE
W234	KLQHRFCWLRFMVEV
S340	GFEVAFTSSQDKAFD
A345	FTSSQDKAFDsDSEP
S348-p	SQDKAFDsDSEPDAV

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