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Protein Page:
CAMK1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CAMK1A an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK1 family
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytoplasm; nucleus
Molecular Function: calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: positive regulation of protein export from nucleus; positive regulation of synapse structural plasticity; regulation of muscle cell differentiation; regulation of protein localization; regulation of protein binding; positive regulation of muscle cell differentiation; nucleocytoplasmic transport; cell cycle; signal transduction; protein amino acid phosphorylation
Reference #:  Q14012 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase type 1; CaM kinase I; CaM kinase I alpha; CaM-KI; CAMK1; CAMKI; CaMKI-alpha; KCC1A; MGC120317; MGC120318
Gene Symbols: CAMK1
Molecular weight: 41,337 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Select Structure to View Below

CAMK1A

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y20-p AEDIRDIyDFRDVLG
1 0 K59-ub AKEALEGkEGSMENE
0 2 Y131-p QVLDAVKyLHDLGIV
0 1 Y150 KPENLLYYSLDEDSK
0 4 S176-p EDPGSVLstACGTPG
8 11 T177-p DPGSVLstACGTPGY
0 1 T181 VLstACGTPGYVAPE
0 2 Y235-p EQILKAEyEFDSPYW
0 1 T323-p MRKLQLGtsQEGQGQ
0 1 S324-p RKLQLGtsQEGQGQT
0 1 S363-p VEPGTELsPTLPHQL
  mouse

 
Y20 AEDIRDIYDFRDVLG
K59 AKKALEGKEGSMENE
Y131 QVLDAVKYLHDLGIV
Y150-p KPENLLYySLDEDSK
S176-p EDPGSVLstACGtPG
T177-p DPGSVLstACGtPGY
T181-p VLstACGtPGYVAPE
Y235 EQILKAEYEFDSPYW
T323-p MRKLQLGtSQEGQGQ
S324 RKLQLGtSQEGQGQT
P363 VEPGSELPPAPPPSS
  rat

 
Y20 AEDIRDIYDFRDVLG
K59 AKKALEGKEGSMENE
Y131 QVLDAVKYLHDLGIV
Y150 KPENLLYYSLDEDSK
S176 EDPGSVLStACGTPG
T177-p DPGSVLStACGTPGY
T181 VLStACGTPGYVAPE
Y235-p EQILKAEyEFDSPYW
T323 MRKLQLGTSQEGQGQ
S324 RKLQLGTSQEGQGQT
P363 VEPGSELPPAPPPSS
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