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Protein Page:
MOB1A (human)

Overview
MOB1A Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Protein kinase, regulatory subunit
Cellular Component: cytosol
Molecular Function: protein binding; metal ion binding
Reference #:  Q9H8S9 (UniProtKB)
Alt. Names/Synonyms: C2orf6; FLJ10788; FLJ11595; MATS1; MOB1; Mob1 alpha; Mob1 homolog 1B; MOB1, Mps One Binder kinase activator-like 1B (yeast); Mob1A; MOB4B; MOBK1B; MOBKL1B; MOL1B; Mps one binder kinase activator-like 1B; Protein Mob4B
Gene Symbols: MOB1A
Molecular weight: 25,080 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MOB1A

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T74‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsFLFSSRS
0 2 S23-p KKNIPEGsHQyELLK
0 149 Y26-p IPEGsHQyELLKHAE
0 48 T35-p LLKHAEAtLGsGNLR
0 17 S38-p HAEAtLGsGNLRQAV
1 0 T74-p QINMLYGtITEFCTE
8699 : Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb
  mouse

 
S2 ______MSFLFSSRS
S23 KKNIPEGSHQYELLK
Y26 IPEGSHQYELLKHAE
T35-p LLKHAEAtLGsGNLR
S38-p HAEAtLGsGNLRQAV
T74 QINMLYGTITEFCTE
8699 : Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb
  rat

 
S2 ______MSFLFSSRS
S23 KKNIPEGSHQYELLK
Y26 IPEGSHQYELLKHAE
T35 LLKHAEATLGSGNLR
S38 HAEATLGSGNLRQAV
T74 QINMLYGTITEFCTE
8699 : Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb
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