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Protein Page:
PHF20 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PHF20 Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein; Acetyltransferase; Nuclear envelope
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; DNA binding; zinc ion binding; histone acetyltransferase activity (H4-K16 specific)
Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  Q9BVI0 (UniProtKB)
Alt. Names/Synonyms: C20orf104; FLJ33479; GLEA2; Glioma-expressed antigen 2; HCA58; Hepatocellular carcinoma-associated antigen 58; NZF; PHD finger protein 20; PHF20; Transcription factor TZP; TZP
Gene Symbols: PHF20
Molecular weight: 115,386 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PHF20

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S291‑p
cell cycle regulation: S291‑p
cell growth, induced: S291‑p
transcription, inhibited: S291‑p
intracellular localization: S291‑p
molecular association, regulation: S291‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K48 GKVLIHFKRWNHRYD
0 1 Y103-p CWSDCRFyPAKVTAV
0 1 Y116-p AVNKDGTyTVKFYDG
0 1 S158-p TDHKSLSssPDKREK
0 1 S159-p DHKSLSssPDKREKF
0 1 K177-m2 RKATVNVkKDKEDKP
0 1 Y231-p ISENDREysGDAQVD
0 1 S232-p SENDREysGDAQVDK
1 1 S265-p RKRGRPPsIAPTAVD
0 1 T277 AVDSNSQTLQPITLE
2 0 S291-p ELRRRKIsKGCEVPL
0 4 S328-p KDLSRRRsSRLstNG
0 4 S332-p RRRsSRLstNGTHEI
0 1 T333-p RRsSRLstNGTHEIL
0 1 S347-p LDPDLVVsDLVDTDP
0 1 L359 TDPLQDTLSsTKEsE
0 1 S361-p PLQDTLSsTKEsEEG
0 1 S365-p TLSsTKEsEEGQLKS
0 1 T408-p CPSMGENtMKtEPTS
0 2 T411-p MGENtMKtEPTSPLV
0 2 S415 tMKtEPTSPLVELQE
0 1 S424-p LVELQEIsTVEVTNT
0 1 S482 YFHGMEKSLEPEEsP
0 5 S488-p KSLEPEEsPGKRHVQ
0 1 P505 GPSASDKPSQETLTR
0 1 S506 PSASDKPSQETLTRK
0 1 S802-p IPVTDTRsKEEAPSY
0 2 K843-ac TSEHCYQkPRAYYPA
0 6 S878-p LHENGDDsLsPRLGW
0 8 S880-p ENGDDsLsPRLGWPL
0 2 S902-p DSDPKPGsPKVKEYV
  mouse

 
K48-m1 GRVLIHFkRWNHRYD
Y103 CWSDCRFYPARVTAV
Y116 AVNKDGTYTVKFYDG
S158 TDHKSLSSSPEKREK
S159 DHKSLSSSPEKREKF
K177 RKVTVNVKKDKVEKA
Y231 ISENEREYSGDAQVE
S232 SENEREYSGDAQVEK
S265 RKRGRPPSITPTAVD
T277-p AVDSNSQtLQPITLE
S291 ELRRRKISKRSDTPL
S328 KDLSRRRSSRLSTNG
S332 RRRSSRLSTNGTREI
T333 RRSSRLSTNGTREIL
P347 LDPDSIVPDLVHTVD
S362-p TNPLPDKsPSAKDSA
S364 PLPDKsPSAKDSAEG
S368 KsPSAKDSAEGQLKS
T411 CKSMGENTMKTEPVs
T414 MGENTMKTEPVsPLA
S418-p TMKTEPVsPLAEVQE
S427 LAEVQEVSTVEVPNT
S485-p YFHGMEKsPEPEEGP
G491 KsPEPEEGPGKTHVQ
T508-p GSAVPDKtsQESLTR
S509-p SAVPDKtsQESLTRK
S805 IHITDARSEESPSYR
K841 TSEHCYQKPRAYYPA
S876-p LCENGDDsLsPRLGW
S878-p ENGDDsLsPRLGWPI
S900-p DIDPKPSsPKVREYI
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