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Protein Page:
BID (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BID a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Apoptosis
Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding; death receptor binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of apoptosis; apoptosis; positive regulation of protein homooligomerization; DNA damage response, signal transduction; response to estradiol stimulus; regulation of cell proliferation; positive regulation of protein oligomerization; apoptotic mitochondrial changes; neuron apoptosis; induction of apoptosis via death domain receptors; brain development; protein targeting to mitochondrion; protein homooligomerization
Reference #:  P55957 (UniProtKB)
Alt. Names/Synonyms: apoptic death agonist; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; FP497; Human BID coding sequence; MGC15319; MGC42355; p11 BID; p13 BID; p15 BID; p22 BID
Gene Symbols: BID
Molecular weight: 21,995 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BID

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 246 Y54-p LAPQWEGyDELQtDG
1 1 T59-p EGyDELQtDGNRSSH
3 0 N62 DELQtDGNRSSHsRL
3 0 S65 QtDGNRSSHsRLGRI
1 1 S67-p DGNRSSHsRLGRIEA
5 1 S78-p RIEADSEsQEDIIRN
0 1 R123 TSRSEEDRNRDLATA
0 1 T129 DRNRDLATALEQLLQ
0 1 L135 ATALEQLLQAYPRDM
0 29 K158-ub LALLLAKkVASHTPS
  BID iso2  
S3-p _____MCsGAGVMMA
Y100 LAPQWEGYDELQTDG
T105 EGYDELQTDGNRSSH
N108 DELQTDGNRSSHSRL
S111 QTDGNRSSHSRLGRI
S113 DGNRSSHSRLGRIEA
S124 RIEADSESQEDIIRN
R169 TSRSEEDRNRDLATA
T175 DRNRDLATALEQLLQ
L181 ATALEQLLQAYPRDM
K204 LALLLAKKVASHTPS
  mouse

 
- gap
E53 AYWEADLEDELQtDG
T58-p DLEDELQtDGsQAsR
S61-p DELQtDGsQAsRsFN
S64-p QtDGsQAsRsFNQGR
S66-p DGsQAsRsFNQGRIE
S78-p RIEPDSEsQEEIIHN
K123-ub GSLSEEDkRNCLAkA
K129-ub DkRNCLAkALDEVkT
K135-ub AkALDEVkTAFPRDM
K158 MTMLLAKKVASHAPS
  rat

 
- gap
E54 VYLEGDREDELQTDG
T59 DREDELQTDGSRASR
S62 DELQTDGSRASRSFY
S65 QTDGSRASRSFYHGR
S67 DGSRASRSFYHGRIE
S79-p RIEPDSEsQDEVIHN
K124 GSLSEEDKRNCLAKA
K130 DKRNCLAKALDEVKT
K136 AKALDEVKTSFPRDM
K159 MTMLLAKKVASHAPS
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