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RBM17 (human)

Overview RBM17 Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Note: This description may include information from UniProtKB. Protein type: RNA splicing; RNA binding protein Cellular Component: spliceosome; nucleolus; nucleus Molecular Function: protein binding; RNA binding; nucleotide binding Biological Process: RNA splicing; mRNA processing Reference #:  Q96I25 (UniProtKB) Alt. Names/Synonyms: 45 kDa-splicing factor; DKFZp686F13131; MGC14439; RBM17; RNA binding motif protein 17; RNA-binding motif protein 17; SPF45; Splicing factor 45; splicing factor 45kDa Gene Symbols: RBM17 Molecular weight: 44,962 Da Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states

Select Structure to View Below RBM17 2PE8 - A=301-401 (human) 2PEH - A/B=301-401 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2PE8 2PEH  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T11	YDDLGVETSDSKTEG
0	1		S12	DDLGVETSDSKTEGW
0	1		S14	LGVETSDSKTEGWSk
0	1		K21-a	SKTEGWSkNFKLLQs
0	1		S28-p	kNFKLLQsQLQVKKA
0	2		K58-a	LAPVIDLkRGGSSDD
1	11		T71-p	DDRQIVDtPPHVAAG
0	1		S85-p	GLKDPVPsGFSAGEV
0	1		K129-a	QRELERQkEIEEREK
0	321		S155-p	ARRPDPDsDEDEDyE
0	239		Y161-p	DsDEDEDyERERRKR
0	13		S169-p	ERERRKRsMGGAAIA
0	1		T179-p	GAAIAPPtsLVEKDK
0	1		S180-p	AAIAPPtsLVEKDKE
0	7		Y194-p	ELPRDFPyEEDSRPR
0	1		S204-p	DSRPRSQsSKAAIPP
0	4		Y214-p	AAIPPPVyEEQDRPR
1	11		S222-p	EEQDRPRsPtGPsNs
0	5		T224-p	QDRPRsPtGPsNsFL
0	2		S227-p	PRsPtGPsNsFLANM
0	2		S229-p	sPtGPsNsFLANMGG
0	1		T237	FLANMGGTVAHKIMQ
0	1		S293-p	DASKKSDsNPLTEIL
0	1		K327	EDLEVETKEECEKYG
0	1		K332	ETKEECEKYGKVGKC
0	1		K338	EKYGKVGKCVIFEIP

	mouse
T11-p	YDDLGVEtsDsKTEG
S12-p	DDLGVEtsDsKTEGW
S14-p	LGVEtsDsKTEGWSK
K21	sKTEGWSKNFKLLQS
S28	KNFKLLQSQLQVKKA
K58-a	LAPVIDLkRGGSSDD
T71-p	DDRQIADtPPHVAAG
S85	GLKDPVPSGFSAGEV
K129	QRELERQKEIEEREK
S155-p	SRRPDPDsDEDEDyE
Y161-p	DsDEDEDyERERRKR
S169-p	ERERRKRsMGGAAIA
T179	GAAIAPPTSLVEKDK
S180	AAIAPPTSLVEKDKE
Y194	ELPRDFPYEEDSRPR
S204	DSRPRSQSSKAAIPP
Y214	AAIPPPVYEEPDRPR
S222-p	EEPDRPRsPtGPSNS
T224-p	PDRPRsPtGPSNSFL
S227	PRsPtGPSNSFLANM
S229	sPtGPSNSFLANMGG
T237-p	FLANMGGtVAHKIMQ
S297	DASKKSDSNPLTEIL
K331-a	EDLEVETkEECEkYG
K336-a	ETkEECEkYGKVGkC
K342-a	EkYGKVGkCVIFEIP

	rat
T11	YDDLGVETSDSKTEG
S12	DDLGVETSDSKTEGW
S14	LGVETSDSKTEGWSK
K21	SKTEGWSKNFKLLQS
S28	KNFKLLQSQLQVKKA
K58	LAPVIDLKRGGSSDD
T71	DDRQIVDTPPHVAAG
S85	GLKDPVPSGFSAGEV
K129	QRELERQKEIEEREK
S155-p	SRRPDPDsDEDEDyE
Y161-p	DsDEDEDyERERRKR
S169	ERERRKRSMGGAAIA
T179	GAAIAPPTSLVEKDK
S180	AAIAPPTSLVEKDKE
Y194	ELPRDFPYEEDSRPR
S204	DSRPRSQSSKAAIPP
Y214	AAIPPPVYEEPDRPR
S222	EEPDRPRSPTGPSNS
T224	PDRPRSPTGPSNSFL
S227	PRSPTGPSNSFLANM
S229	SPTGPSNSFLANMGG
T237	FLANMGGTVAHKIMQ
S297	DASKKSDSNPLTEIL
K331	EDLEVETKEECEKYG
K336	ETKEECEKYGKVGKC
K342	EKYGKVGKCVIFEIP

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