Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix; Secreted; Inhibitor protein
Molecular Function: metalloendopeptidase inhibitor activity; integrin binding; protein binding; metal ion binding; enzyme activator activity
Biological Process: response to drug; negative regulation of proteolysis; regulation of Rap protein signal transduction; extracellular matrix organization and biogenesis; central nervous system development; negative regulation of cell proliferation; extracellular matrix disassembly; positive regulation of MAPKKK cascade; response to cytokine stimulus; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; aging