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TIMP2 (human)

Overview TIMP2 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; Extracellular matrix; Secreted; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis Cellular Component: cell surface; extracellular region; basement membrane Molecular Function: metalloendopeptidase inhibitor activity; integrin binding; metal ion binding; enzyme activator activity Biological Process: negative regulation of cell proliferation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; regulation of neuron differentiation; regulation of cAMP metabolic process; regulation of MAPKKK cascade Reference #:  P16035 (UniProtKB) Alt. Names/Synonyms: CSC-21K; metalloproteinase inhibitor 2; TIMP2; tissue inhibitor of metalloproteinase 2 Gene Symbols: TIMP2 Molecular weight: 24,399 Da Basal Isoelectric point: 7.46  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TIMP2 1BR9 - A=27-220 (human) 2TMP - A=27-153 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1BR9 1GXD 2TMP  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S57-p	VSEKEVDsGNDIyGN
0	1		Y62-p	VDsGNDIyGNPIKRI

	mouse
S57	VSEKEVDSGNDIYGN
Y62	VDSGNDIYGNPIKRI

	rat
S57	VSEKEVDSGNDIYGN
Y62	VDSGNDIYGNPIKRI

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