May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Belongs to the ZPR1 family. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: nucleoplasm; Cajal body; growth cone; cell soma; perinuclear region of cytoplasm; axon; cytoplasm; nucleolus; SMN complex; perikaryon; nucleus
Molecular Function: protein binding; zinc ion binding; translation initiation factor binding; receptor tyrosine kinase binding
Biological Process: regulation of myelination; trophectodermal cell proliferation; RNA splicing; DNA endoreduplication; Cajal body organization and biogenesis; microtubule cytoskeleton organization and biogenesis; signal transduction; positive regulation of RNA splicing; inner cell mass cell proliferation; cell proliferation; positive regulation of protein import into nucleus; spinal cord development; mRNA processing; positive regulation of growth
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.