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Protein Page:
rubicon (human)

Overview
rubicon Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity. Forms a complex with BECN1, PIK3C3, PIK3R4 and UVRAG, but not with ATG14. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: Golgi apparatus; lysosome; late endosome; early endosome
Molecular Function: protein binding
Biological Process: negative regulation of autophagy; negative regulation of endocytosis; autophagy; endocytosis
Reference #:  Q92622 (UniProtKB)
Alt. Names/Synonyms: hypothetical protein LOC9711; K0226; KIAA0226; Uncharacterized protein KIAA0226
Gene Symbols: KIAA0226
Molecular weight: 108,622 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

rubicon

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S197-p MFARKHEsPLLVTKS
0 1 S206 LLVTKSQSLTALPSS
0 1 S225 PNSYAQHSYFGSFSS
0 1 Y226 NSYAQHSYFGSFSSL
0 1 S246 NNGSERRSTsFPLSG
0 4 S248-p GSERRSTsFPLSGPP
0 4 S266-p QESRGHVsPAEDQtI
0 1 T272-p VsPAEDQtIQAPPVS
0 7 S387-p LSSVLRRssFSEGQT
0 52 S388-p SSVLRRssFSEGQTL
0 2 S390 VLRRssFSEGQTLTV
0 19 S410-p KSHIRSHsDTSIASR
0 8 Y449-p VSTPSSLyMEYEGGR
0 6 S469-p EGMFRRPsEGQSLIS
0 3 S528-p EEVEEEDsDREIQEL
0 1 S562-p YQEAEHGsFRVTSSS
0 1 S577-p SQFSSRDsAQLsDsG
0 2 S581-p SRDsAQLsDsGsADE
0 3 S583-p DsAQLsDsGsADEVD
0 2 S585-p AQLsDsGsADEVDEF
0 4 S671-p IPDSLPIsPDDGQHA
0 2 T709-p FNVHPAPtRKIAVAK
  mouse

► Hide Isoforms
 
S198-p MFARKQEsPLLVTKS
S207-p LLVTKSQsLTALPGS
S226-p PASYAQHsyFGSSSS
Y227-p ASYAQHsyFGSSSSL
S248-p SHSSERRsTSFSLSG
S250 SSERRsTSFSLSGPS
S268 QEDRECLSPAETQTT
T274 LSPAETQTTPAPLPS
S389-p AGSVLRRssFsEGQT
S390-p GSVLRRssFsEGQTA
S392-p VLRRssFsEGQTAPV
S412-p KSHIRSHsDTNIASR
- gap
S454-p EGMFRRPsEGQSLIS
S513 EEVEEEDSDREIQEL
S547 YRETENGSFRVTSSS
S562 SQFSSRDSTQLSEsG
S566 SRDSTQLSEsGSAED
S568-p DSTQLSEsGSAEDAD
S570 TQLSEsGSAEDADDL
S655 IPDSLPISPDDGQHA
T693 FNVHPAPTRKIAVAK
  rubicon iso2  
S198 MFARKQESPLLVTKS
S207 LLVTKSQSLTALPGS
S226 PASYAQHSYFGSSSS
Y227 ASYAQHSYFGSSSSL
S248 SHSSERRSTSFSLSG
S250 SSERRSTSFSLSGPS
S268 QEDRECLSPAETQTT
T274 LSPAETQTTPAPLPS
S389 AGSVLRRSSFSEGQT
S390 GSVLRRSSFSEGQTA
S392 VLRRSSFSEGQTAPV
S412 KSHIRSHSDTNIASR
- gap
S439 EGMFRRPSEGQSLIS
S498 EEVEEEDSDREIQEL
S532 YRETENGSFRVTSSS
S547 SQFSSRDSTQLSESG
S551 SRDSTQLSESGSAED
S553 DSTQLSESGSAEDAD
S555 TQLSESGSAEDADDL
S640 IPDSLPISPDDGQHA
T678 FNVHPAPTRKIAVAK
  rubicon iso3  
S198 MFARKQESPLLVTKS
S207 LLVTKSQSLTALPGS
S226 PASYAQHSYFGSSSS
Y227 ASYAQHSYFGSSSSL
S248 SHSSERRSTSFSLSG
S250 SSERRSTSFSLSGPS
S268 QEDRECLSPAETQTT
T274 LSPAETQTTPAPLPS
S375 AGSVLRRSSFSEGQT
S376 GSVLRRSSFSEGQTA
S378 VLRRSSFSEGQTAPV
S398 KSHIRSHSDTNIASR
- gap
S425 EGMFRRPSEGQSLIS
S484 EEVEEEDSDREIQEL
S518 YRETENGSFRVTSSS
S533 SQFSSRDSTQLSESG
S537 SRDSTQLSESGSAED
S539 DSTQLSESGSAEDAD
S541 TQLSESGSAEDADDL
S626 IPDSLPISPDDGQHA
T664 FNVHPAPTRKIAVAK
  rubicon iso4  
S137 MFARKQESPLLVTKS
S146 LLVTKSQSLTALPGS
S165 PASYAQHSYFGSSSS
Y166 ASYAQHSYFGSSSSL
S187 SHSSERRSTSFSLSG
S189 SSERRSTSFSLSGPS
S207 QEDRECLSPAETQTT
T213 LSPAETQTTPAPLPS
S314 AGSVLRRSSFSEGQT
S315 GSVLRRSSFSEGQTA
S317 VLRRSSFSEGQTAPV
S337 KSHIRSHSDTNIASR
- gap
S364 EGMFRRPSEGQSLIS
S423 EEVEEEDSDREIQEL
S457 YRETENGSFRVTSSS
S472 SQFSSRDSTQLSESG
S476 SRDSTQLSESGSAED
S478 DSTQLSESGSAEDAD
S480 TQLSESGSAEDADDL
S565 IPDSLPISPDDGQHA
T603 FNVHPAPTRKIAVAK
  rat

 
S197 MFARKQESPLLVTKS
S206 LLVTKSQSLTALPGS
S225 PTSCAQHSYFGSSSS
Y226 TSCAQHSYFGSSSSL
S247 SHSSERRSTSFSLSG
S249 SSERRSTSFSLSGPP
S267 QEDRECLSAAETQTT
T273 LSAAETQTTQAPLLS
S395 AGSTLRRSSFSEGQT
S396 GSTLRRSSFSEGQTV
S398 TLRRSSFSEGQTVPA
S418 KSHIRSHSDTNIASR
- gap
S445-p EGMFRRPsEGQSLIS
S504 EEVEEEDSDREIQEL
S538 YQETEHGSFRVTSSS
S553 SQFSSRDSTQLSDSG
S557 SRDSTQLSDSGSAED
S559 DSTQLSDSGSAEDVD
S561 TQLSDSGSAEDVDEF
S646 IPDSLPISPDDGQHA
T684 FNVHPAPTRKIAVAK
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