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Protein Page:
OSM (mouse)

Overview
OSM Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Cytokine; Secreted
Cellular Component: extracellular space; oncostatin-M receptor complex; extracellular region
Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity
Biological Process: negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; regulation of growth; positive regulation of cell proliferation; negative regulation of meiosis; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response
Reference #:  P53347 (UniProtKB)
Alt. Names/Synonyms: ONCM; oncostatin M; Oncostatin-M; OSM; OTTMUSP00000005249
Gene Symbols: Osm
Molecular weight: 30,114 Da
Basal Isoelectric point: 11.78  Predict pI for various phosphorylation states
Select Structure to View Below

OSM

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 T95 SKPHFLSTVYTTLDR
0 1 T99 FLSTVYTTLDRVLYQ
0 1 G200 VFREWDDGSTRSRRQ
0 1 S204 WDDGSTRSRRQSPLR
0 1 T237 IRVRRKGTRRIWVRR
0 1 I240 RRKGTRRIWVRRKGS
  human

 
T98-p GRRGFLQtLNAtLGC
T102-p FLQtLNAtLGCVLHR
S215-p VFSKWGEsPNRsRRH
S219-p WGEsPNRsRRHSPHQ
T235-p LRKGVRRtRPsRKGK
S238-p GVRRtRPsRKGKRLM
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