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OSM (mouse)

Overview OSM Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted; Cytokine Cellular Component: extracellular space; oncostatin-M receptor complex; extracellular region Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity Biological Process: apoptosis; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-serine phosphorylation; tyrosine phosphorylation of Stat5 protein; peripheral nervous system development; behavioral response to pain; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to heat; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter Reference #:  P53347 (UniProtKB) Alt. Names/Synonyms: ONCM; oncostatin M; Oncostatin-M; OSM; OTTMUSP00000005249 Gene Symbols: Osm Molecular weight: 30,114 Da Basal Isoelectric point: 11.78  Predict pI for various phosphorylation states

Select Structure to View Below OSM 1EVS - A=26-212 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T95	SKPHFLSTVYTTLDR
0	1		T99	FLSTVYTTLDRVLYQ

	human
T98-p	GRRGFLQtLNAtLGC
T102-p	FLQtLNAtLGCVLHR

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