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Protein Page:
OSM (human)

Overview
OSM Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space; oncostatin-M receptor complex
Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity
Biological Process: negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; behavioral response to pain; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to heat; positive regulation of acute inflammatory response; regulation of growth; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of meiosis; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P13725 (UniProtKB)
Alt. Names/Synonyms: MGC20461; ONCM; oncostatin M; Oncostatin-M; OSM
Gene Symbols: OSM
Molecular weight: 28,484 Da
Basal Isoelectric point: 10.71  Predict pI for various phosphorylation states
Select Structure to View Below

OSM

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T98-p GRRGFLQtLNAtLGC
0 1 T102-p FLQtLNAtLGCVLHR
0 1 S215-p VFSKWGEsPNRsRRH
0 1 S219-p WGEsPNRsRRHSPHQ
0 1 T235-p LRKGVRRtRPsRKGK
0 1 S238-p GVRRtRPsRKGKRLM
  mouse

 
T95 SKPHFLSTVYTTLDR
T99 FLSTVYTTLDRVLYQ
G200 VFREWDDGSTRSRRQ
S204 WDDGSTRSRRQSPLR
T237 IRVRRKGTRRIWVRR
I240 RRKGTRRIWVRRKGS
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