Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Cytokine
Biological Process: multicellular organismal development; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-serine phosphorylation; tyrosine phosphorylation of Stat5 protein; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; positive regulation of acute inflammatory response; positive regulation of cell division; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.