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WNT5B (human)

Overview WNT5B Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Interacts with PORCN. Belongs to the Wnt family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; plasma membrane Molecular Function: receptor binding; frizzled-2 binding Biological Process: fat cell differentiation; convergent extension involved in axis elongation; Wnt receptor signaling pathway; wound healing; convergent extension involved in gastrulation; dorsal/ventral axis specification; endocrine pancreas development; neuron differentiation; anterior/posterior pattern formation; Wnt receptor signaling pathway, calcium modulating pathway; chondrocyte differentiation; positive regulation of fat cell differentiation; angiogenesis; cell migration involved in gastrulation; positive regulation of cell migration Reference #:  Q9H1J7 (UniProtKB) Alt. Names/Synonyms: MGC2648; Protein Wnt-5b; wingless-type MMTV integration site family, member 5B; WNT-5B protein; WNT5B Gene Symbols: WNT5B Molecular weight: 40,323 Da Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WNT5B

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y249-p	GDRLKEKyDSAAAMR

	mouse
Y249	GDRLKEKYDSAAAMR

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