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Epigen (human)

Overview Epigen Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral Cellular Component: integral to plasma membrane; extracellular region Molecular Function: MAP kinase kinase activity; growth factor activity; epidermal growth factor receptor binding Biological Process: positive regulation of MAP kinase activity; positive regulation of epidermal growth factor receptor activity; positive regulation of mitosis; activation of MAPK activity; positive regulation of cell proliferation; angiogenesis; positive regulation of epithelial cell proliferation Reference #:  Q6UW88 (UniProtKB) Alt. Names/Synonyms: EPG; EPGN; epigen; epithelial mitogen homolog Gene Symbols: EPGN Molecular weight: 17,091 Da Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling

Select Structure to View Below Epigen

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  ENZYME  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y144	CLKLKSPYNVCSGER

	mouse
Y143-p	CINLKSPyIICSGGS

	rat
Y173	CLNVKSPYIICSGGR

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