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TweakR (human)

Overview TweakR Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc.; Cell development/differentiation; Motility/polarity/chemotaxis Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane Molecular Function: protein binding Biological Process: substrate-bound cell migration, cell attachment to substrate; apoptosis; positive regulation of axon extension; multicellular organismal development; induction of apoptosis; angiogenesis; cell motility Reference #:  Q9NP84 (UniProtKB) Alt. Names/Synonyms: FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; FN14; TNFRSF12A; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; type I transmembrane protein Fn14; TweakR Gene Symbols: TNFRSF12A Molecular weight: 13,911 Da Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TweakR 2EQP - A=28-70 (human) 2KMZ - A=28-80 (human) 2RPJ - A=28-70 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2EQP 2KMZ 2RPJ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T117	FTTPIEETGGEGCPA

	mouse
T117-p	FTTPIEEtGGEGCPG

	rat
T117	FTTPIEETGGEGCPG

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