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LAMTOR2
Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
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Cellular Component: lysosomal membrane; late endosome
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Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold
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Biological Process: activation of MAPKK activity; cell growth; positive regulation of TOR signaling pathway
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Reference #:
Q9Y2Q5 (UniProtKB)
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| Alt. Names/Synonyms: ENDAP; endosomal adaptor protein p14; HSPC003; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; late endosomal/lysosomal Mp1-interacting protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen-activated protein-binding protein-interacting protein; P14; Ragulator2; roadblock domain containing 3; roadblock domain-containing protein 3; ROBLD3 |
| Gene Symbols: LAMTOR2 |
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Molecular weight: 13,508 Da
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Basal Isoelectric point: 5.3
Predict pI for various phosphorylation states
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CST Pathways:
MAPK/Erk in Growth and Differentiation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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