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Protein Page:
LAMTOR2 (human)

Overview
LAMTOR2 Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: lysosomal membrane; late endosome
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold
Biological Process: activation of MAPKK activity; cell growth; positive regulation of TOR signaling pathway; positive regulation of GTPase activity
Reference #:  Q9Y2Q5 (UniProtKB)
Alt. Names/Synonyms: ENDAP; endosomal adaptor protein p14; HSPC003; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; late endosomal/lysosomal Mp1-interacting protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen-activated protein-binding protein-interacting protein; P14; Ragulator2; roadblock domain containing 3; roadblock domain-containing protein 3; ROBLD3
Gene Symbols: LAMTOR2
Molecular weight: 13,508 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LAMTOR2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 N68 NQAFNEDNLKFILMD
0 1 S125 PLTQVAAS_______
  mouse

 
S68-p NQAFNEDsLKFILMD
S125-p PLTQVAAs_______
  rat

 
S68 NQAFNEDSLKFILMD
S125 PLTQVAAS_______
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