Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
LAMTOR2 (human)

LAMTOR2 Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: lysosomal membrane; late endosome; endosome membrane
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; macroautophagy; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; gene expression; cell cycle arrest; cell growth; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway; positive regulation of GTPase activity
Disease: Immunodeficiency Due To Defect In Mapbp-interacting Protein
Reference #:  Q9Y2Q5 (UniProtKB)
Alt. Names/Synonyms: ENDAP; endosomal adaptor protein p14; HSPC003; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; late endosomal/lysosomal Mp1-interacting protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen-activated protein-binding protein-interacting protein; P14; Ragulator2; roadblock domain containing 3; roadblock domain-containing protein 3; ROBLD3
Gene Symbols: LAMTOR2
Molecular weight: 13,508 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S125 PLTQVAAS_______

S125-p PLTQVAAs_______

S125 PLTQVAAS_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.