Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
DKK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DKK2 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Inhibitor protein
Cellular Component: extracellular space
Biological Process: Wnt receptor signaling pathway; multicellular organismal development
Reference #:  Q9UBU2 (UniProtKB)
Alt. Names/Synonyms: dickkopf 2; dickkopf homolog 2; dickkopf related protein-2; dickkopf-2; dickkopf-related protein 2; Dkk-2; DKK2
Gene Symbols: DKK2
Molecular weight: 28,447 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DKK2

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y58-p ANRSAGMyQGLAFGG
0 1 Y89-p KECEVGRyCHsPHQG
0 1 S92-p EVGRyCHsPHQGssA
0 1 S97-p CHsPHQGssACMVCR
0 1 S98-p HsPHQGssACMVCRR
0 1 Y155-p RDRNHGHysNHDLGW
0 1 S156-p DRNHGHysNHDLGWQ
0 1 K250-ac KDATYSSkARLHVCQ
  mouse

 
N58 ANRSAGMNQGLAFGG
Y89 KECEVGRYCHSPHQG
S92 EVGRYCHSPHQGSSA
S97 CHSPHQGSSACMLCR
S98 HSPHQGSSACMLCRR
Y155 RDRNHGHYSNHDLGW
S156 DRNHGHYSNHDLGWQ
K250 KDATYSSKARLHVCQ
  rat

 
N58 ANRSAGMNQGLAFGG
Y89 KECEVGRYCHSPHQG
S92 EVGRYCHSPHQGSSA
S97 CHSPHQGSSACMVCR
S98 HSPHQGSSACMVCRR
Y155 RDRNHGHYSNHDLGW
S156 DRNHGHYSNHDLGWQ
K250 KDATYSSKARLHVCQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.