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DKK2 (human)

Overview DKK2 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; Secreted; Secreted, signal peptide Cellular Component: extracellular space Biological Process: Wnt receptor signaling pathway; multicellular organismal development Reference #:  Q9UBU2 (UniProtKB) Alt. Names/Synonyms: dickkopf 2; dickkopf homolog 2; dickkopf related protein-2; dickkopf-2; dickkopf-related protein 2; Dkk-2; DKK2 Gene Symbols: DKK2 Molecular weight: 28,447 Da Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DKK2 2JTK - A=172-259 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y89-p	KECEVGRyCHsPHQG
0	1		S92-p	EVGRyCHsPHQGssA
0	1		S97-p	CHsPHQGssACMVCR
0	1		S98-p	HsPHQGssACMVCRR
0	1		Y155-p	RDRNHGHysNHDLGW
0	1		S156-p	DRNHGHysNHDLGWQ
0	1		K250-a	KDATYSSkARLHVCQ

	mouse
Y89	KECEVGRYCHSPHQG
S92	EVGRYCHSPHQGSSA
S97	CHSPHQGSSACMLCR
S98	HSPHQGSSACMLCRR
Y155	RDRNHGHYSNHDLGW
S156	DRNHGHYSNHDLGWQ
K250	KDATYSSKARLHVCQ

	rat
Y89	KECEVGRYCHSPHQG
S92	EVGRYCHSPHQGSSA
S97	CHSPHQGSSACMVCR
S98	HSPHQGSSACMVCRR
Y155	RDRNHGHYSNHDLGW
S156	DRNHGHYSNHDLGWQ
K250	KDATYSSKARLHVCQ

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