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Protein Page:
ERP44 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERP44 Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress. Note: This description may include information from UniProtKB.
Protein type: Secreted; Endoplasmic reticulum; Isomerase; Secreted, signal peptide
Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment
Molecular Function: protein binding; protein disulfide isomerase activity
Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein
Reference #:  Q9BS26 (UniProtKB)
Alt. Names/Synonyms: endoplasmic reticulum resident protein 44 kDa; ER protein 44; ERP44; KIAA0573; PDIA10; protein disulfide isomerase family A, member 10; thioredoxin domain containing 4 (endoplasmic reticulum); thioredoxin domain-containing protein 4; TXNDC4
Gene Symbols: ERP44
Molecular weight: 46,971 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERP44

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K130 YRGQRSVKALADYIR
0 1 T367-ga FHHGPDPtDtAPGEQ
0 1 T369-ga HGPDPtDtAPGEQAQ
0 1 S380-ga EQAQDVAssPPEssF
0 1 S381-ga QAQDVAssPPEssFQ
0 1 S385-ga VAssPPEssFQKLAP
0 1 S386-ga AssPPEssFQKLAPs
0 1 S393-ga sFQKLAPsEyRYTLL
0 1 Y395-p QKLAPsEyRYTLLRD
  mouse

 
K130-sc YRGQRSVkALADYIR
T367 FHHGPDPTDTAPGEQ
T369 HGPDPTDTAPGEQDQ
S380 EQDQDVASSPPESSF
S381 QDQDVASSPPESSFQ
S385 VASSPPESSFQKLAP
S386 ASSPPESSFQKLAPS
S393 SFQKLAPSEYRYTLL
Y395 QKLAPSEYRYTLLRD
  rat

 
K130 YRGQRSVKALADYIR
T367 FHHGPDPTDTAPGEQ
T369 HGPDPTDTAPGEQDQ
S380 EQDQDVASSPPESSF
S381 QDQDVASSPPESSFQ
S385 VASSPPESSFQKLAP
S386 ASSPPESSFQKLAPS
S393 SFQKLAPSEYRYTLL
Y395 QKLAPSEYRYTLLRD
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