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Protein Page:
SH3GLB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SH3GLB1 May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.-; Mitochondrial; Apoptosis; Autophagy; Transferase
Cellular Component: Golgi membrane; mitochondrial outer membrane; protein complex; cytoplasm
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; lysophosphatidic acid acyltransferase activity; fatty acid binding
Biological Process: positive regulation of protein oligomerization; 'de novo' posttranslational protein folding; apoptosis; phosphatidic acid biosynthetic process; protein oligomerization
Reference #:  Q9Y371 (UniProtKB)
Alt. Names/Synonyms: Bax-interacting factor 1; Bif-1; CGI-61; dJ612B15.2; endophilin B1; Endophilin-B1; KIAA0491; SH3 domain-containing GRB2-like protein B1; SH3-containing protein SH3GLB1; SH3-domain GRB2-like endophilin B1; SH3GLB1; SHLB1
Gene Symbols: SH3GLB1
Molecular weight: 40,796 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SH3GLB1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y80‑p
molecular association, regulation: Y80‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K10 IMDFNVKKLAADAGT
0 1 K61 IWTEKIMKQTEVLLQ
1 267 Y80-p ARIEEFVyEkLDRKA
0 3 K82-ub IEEFVyEkLDRKAPS
1 0 T145 TSALNFLTPLRNFIE
0 2 K355-ub ERGNQKGkVPITYLE
  mouse

 
K10-ub IMDFNVKkLAADAGT
K61-ub IWTEKIMkQTEVLLQ
Y80-p ARIEEFVyEkLDRKA
K82-ub IEEFVyEkLDRKAPS
T145-p TSALNFLtPLRNFIE
K355-ub ERGNQKGkVPITYLE
  rat

 
K10 IMDFNVKKLAADAGT
K61 VWTEKIMKQTEVLLQ
Y80 ARIEEFVYEKLDRKA
K82 IEEFVYEKLDRKAPS
T145 TSALNFLTPLRNFIE
K355 ERGNQKGKVPITYLE
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