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SH3GLB1
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Transferase; Mitochondrial; EC 2.3.1.-; Autophagy; Apoptosis |
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Cellular Component: Golgi membrane; mitochondrial outer membrane; protein complex; cytoplasm
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Molecular Function: identical protein binding; protein binding; protein homodimerization activity; cytoskeletal adaptor activity; lysophosphatidic acid acyltransferase activity; fatty acid binding; SH3 domain binding
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Biological Process: positive regulation of protein oligomerization; 'de novo' posttranslational protein folding; filopodium formation; protein insertion into mitochondrial membrane during induction of apoptosis; phosphatidic acid biosynthetic process; protein oligomerization; negative regulation of apoptosis
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Reference #:
Q9Y371 (UniProtKB)
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| Alt. Names/Synonyms: Bax-interacting factor 1; Bif-1; CGI-61; dJ612B15.2; endophilin B1; Endophilin-B1; KIAA0491; SH3 domain-containing GRB2-like protein B1; SH3-containing protein SH3GLB1; SH3-domain GRB2-like endophilin B1; SH3GLB1; SHLB1 |
| Gene Symbols: SH3GLB1 |
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Molecular weight: 40,796 Da
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Basal Isoelectric point: 5.78
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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