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Protein Page:
RRAGA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RRAGA Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF- alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Belongs to the GTR/RAG GTP-binding protein family. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; GTP binding; protein heterodimerization activity; phosphoprotein binding
Biological Process: cell death; apoptosis; virus-host interaction; positive regulation of cytolysis; positive regulation of TOR signaling pathway
Reference #:  Q7L523 (UniProtKB)
Alt. Names/Synonyms: Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1; FIP1; Rag A; RagA; Ras-related GTP binding A; RRAGA
Gene Symbols: RRAGA
Molecular weight: 36,566 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RRAGA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K244-u QFKLSCSkLAASFQS
0 1 S309-p RVDGPKHsLLMR___
  mouse

 
K244-u QFKLSCSkLAASFQS
S309 RVDGPKHSLLMR___
  rat

 
K244 QFKLSCSKLAASFQS
S309 RVDGPKHSLLMR___
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