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Protein Page:
TGFalpha (human)

Overview
TGFalpha TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell cycle regulation; Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component: extracellular space; cell surface; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; nucleus
Molecular Function: MAP kinase kinase activity; protein binding; growth factor activity; glycoprotein binding; epidermal growth factor receptor binding
Biological Process: response to drug; epidermal growth factor receptor signaling pathway; cell proliferation; positive regulation of mitosis; wound healing; positive regulation of epidermal growth factor receptor activity; activation of MAPK activity; positive regulation of cell division; MAPKKK cascade; angiogenesis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
Reference #:  P01135 (UniProtKB)
Alt. Names/Synonyms: EGF-like TGF; ETGF; TFGA; TGFA; transforming growth factor, alpha
Gene Symbols: TGFA
Molecular weight: 17,006 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TGFalpha

Protein Structure Not Found.


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