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TGFalpha (human)

Overview TGFalpha TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Cell cycle regulation Cellular Component: extracellular space; cell surface; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; nucleus Molecular Function: MAP kinase kinase activity; protein binding; growth factor activity; glycoprotein binding; epidermal growth factor receptor binding Biological Process: response to drug; epidermal growth factor receptor signaling pathway; cytosolic calcium ion homeostasis; wound healing; positive regulation of mitosis; activation of MAPK activity; MAPKKK cascade; cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of cell division; negative regulation of neuron apoptosis; angiogenesis; positive regulation of epithelial cell proliferation Reference #:  P01135 (UniProtKB) Alt. Names/Synonyms: EGF-like TGF; ETGF; TFGA; TGFA; transforming growth factor, alpha Gene Symbols: TGFA Molecular weight: 17,006 Da Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGFalpha 1GK5 - A=83-89 (human) 1YUF - A=40-89 (human) 1YUG - A=40-89 (human) 2TGF - A=40-89 (human) 3E50 - D/C=40-89 (human) 3TGF - A=40-89 (human) 4TGF - A=40-89 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

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