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TDGF1
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Membrane protein, peripheral; Cell cycle regulation; Cell adhesion; Membrane protein, anchored |
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Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; nucleus; lipid raft
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Molecular Function: protein binding; growth factor activity; receptor binding
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Biological Process: epidermal growth factor receptor signaling pathway; activation of MAPK activity; in utero embryonic development; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; regulation of cell migration; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell-matrix adhesion; negative regulation of transforming growth factor beta receptor signaling pathway; vasculogenesis; negative regulation of apoptosis; anterior/posterior axis specification; positive regulation of cell migration
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Reference #:
P51865 (UniProtKB)
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| Alt. Names/Synonyms: CR1; Cripto; Cripto growth factor; Epidermal growth factor-like Cripto protein; Tdgf1; teratocarcinoma-derived growth factor 1 |
| Gene Symbols: Tdgf1 |
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Molecular weight: 18,754 Da
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Basal Isoelectric point: 8.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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