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Protein Page:
TDGF1 (human)

TDGF1 Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft
Molecular Function: protein binding; growth factor activity; receptor binding
Biological Process: activation of MAPK activity; somatic stem cell maintenance; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; cell differentiation; vasculogenesis; epidermal growth factor receptor signaling pathway; in utero embryonic development; morphogenesis of a branching structure; peptidyl-serine phosphorylation; embryonic development; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  P13385 (UniProtKB)
Alt. Names/Synonyms: CR; CRGF; CRIPTO; Epidermal growth factor-like cripto protein CR1; TDGF1; teratocarcinoma-derived growth factor 1
Gene Symbols: TDGF1
Molecular weight: 21,169 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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