an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Kinase, protein; EC 220.127.116.11; Protein kinase, Ser/Thr (non-receptor); Translation; AGC group; RSK family; p70 subfamily
Cellular Component: nucleoplasm; presynaptic active zone; ribosome; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ribosomal protein S6 kinase activity; ATP binding
Biological Process: oogenesis; axon guidance; positive regulation of cell size; cellular response to stress; determination of adult life span; positive regulation of multicellular organism growth; signal transduction; protein amino acid phosphorylation; somatic muscle development; synaptic growth at neuromuscular junction; positive regulation of growth; response to nutrient; larval feeding behavior; myoblast fusion; positive regulation of autophagy; multicellular organism growth; dendrite morphogenesis; actin filament organization; positive regulation of cell growth; positive regulation of organ growth; phagocytosis; lipid metabolic process; regulation of cell size; response to DNA damage stimulus; positive regulation of macroautophagy; growth
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.