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p70S6K (fruit fly)

Overview p70S6K an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Translation; Protein kinase, AGC; EC 2.7.11.-; EC 2.7.11.1; AGC group; RSK family; p70 subfamily Cellular Component: presynaptic active zone; ribosome Molecular Function: protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; ATP binding Biological Process: oogenesis; axon guidance; positive regulation of cell size; cellular response to stress; dendrite morphogenesis; actin filament organization; positive regulation of multicellular organism growth; determination of adult life span; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; positive regulation of organ growth; synaptic growth at neuromuscular junction; phagocytosis, engulfment; regulation of cell size; positive regulation of growth; response to DNA damage stimulus; positive regulation of macroautophagy; response to nutrient; larval feeding behavior; growth Reference #:  NP_523941 (RefSeq) Alt. Names/Synonyms: P70s6k protein kinase homolog; RPS6-p70-protein kinase; S6k; S6K1; s6k11; Tor Gene Symbols: S6k Molecular weight: 55,427 Da Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K

Select Structure to View Below p70S6K 3A60 - A/B=75-399 (human) 3A61 - A=75-399 (human) 3A62 - A=75-399 (human) Substrate Sequence Logo

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			fruit fly
0	1		-	gap
2	0		-	gap
1	0		-	gap
1	0		-	gap
0	1		K109	ANKYFAMKVLKKASI
0	1		K112	YFAMKVLKKASIVTN
0	2		R203	HKLGIIYRDLKPENI
0	2		H229	DFGLCKEHIQEGIVT
0	2		I234	KEHIQEGIVTHTFCG
0	5		T236	HIQEGIVTHTFCGTI
26	10		T238	QEGIVTHTFCGTIEY
0	6		T242	VTHTFCGTIEYMAPE
0	1		T290	NRKKTIETILKAKLN
1	11		I376	DTRFTRQIPVDSPDD
10	9		S380	TRQIPVDSPDDTTLS
1	1		S389	DDTTLSESANLIFQG
286	3		T398	NLIFQGFTYVAPSIL
0	2		Y399	LIFQGFTYVAPSILE
0	1		-	gap
5	1		-	gap
25	1		S418	ANRMPARSPRRTPRQ
8	78		-	gap
92	97		-	gap
88	227		-	gap
1	57		-	gap
1	0		-	gap
1	0		-	gap

	human ► Hide Isoforms
Y11	RRRRDGFYPAPDFRD
S40	DQPEDAGSEDELEEG
S53-p	EGGQLNEsMDHGGVG
Y62	DHGGVGPYELGMEHC
K123	TGKIFAMKVLKKAMI
K126	IFAMKVLKKAMIVRN
R217	HQKGIIYRDLKPENI
S243-p	DFGLCKEsIHDGtVt
T248-p	KEsIHDGtVtHtFCG
T250-p	sIHDGtVtHtFCGtI
T252-p	HDGtVtHtFCGtIEY
T256-p	VtHtFCGtIEYMAPE
K304-a	NRKKTIDkILKCKLN
T390-p	DSKFTRQtPVDsPDD
S394-p	TRQtPVDsPDDSTLS
S403-p	DDSTLSEsANQVFLG
T412-p	NQVFLGFtyVAPSVL
Y413-p	QVFLGFtyVAPSVLE
S421-p	VAPSVLEsVKEKFsF
S427-p	EsVKEKFsFEPKIRs
S434-p	sFEPKIRsPRRFIGs
S441-p	sPRRFIGsPRtPVsP
T444-p	RFIGsPRtPVsPVKF
S447-p	GsPRtPVsPVKFsPG
S452-p	PVsPVKFsPGDFWGR
T470-p	ASTANPQtPVEYPME
K516-a	QAFPMISkRPEHLRM

	p70S6K iso2
-	gap
S17	DQPEDAGSEDELEEG
S30	EGGQLNESMDHGGVG
Y39	DHGGVGPYELGMEHC
K100	TGKIFAMKVLKKAMI
K103	IFAMKVLKKAMIVRN
R194	HQKGIIYRDLKPENI
S220	DFGLCKESIHDGTVT
T225	KESIHDGTVTHtFCG
T227	SIHDGTVTHtFCGTI
T229-p	HDGTVTHtFCGTIEY
T233	VTHtFCGTIEYMAPE
K281	NRKKTIDKILKCKLN
T367	DSKFTRQTPVDSPDD
S371	TRQTPVDSPDDSTLS
S380	DDSTLSESANQVFLG
T389-p	NQVFLGFtYVAPSVL
Y390	QVFLGFtYVAPSVLE
S398	VAPSVLESVKEKFSF
S404	ESVKEKFSFEPKIRS
S411	SFEPKIRSPRRFIGS
S418	SPRRFIGSPRTPVsP
T421	RFIGSPRTPVsPVKF
S424-p	GSPRTPVsPVKFSPG
S429	PVsPVKFSPGDFWGR
T447	ASTANPQTPVEYPME
K493	QAFPMISKRPEHLRM

	mouse
Y11	RRRRDGFYLAPDFRH
S40	DQPEDAGSEDELEEG
S53	EGGQLNESMDHGGVG
Y62	DHGGVGPYELGMEHC
K123-a	TGKIFAMkVLkKAMI
K126-a	IFAMkVLkKAMIVRN
R217-m1	HQKGIIYrDLKPENI
S243-p	DFGLCKEsIHDGtVt
T248-p	KEsIHDGtVtHtFCG
T250-p	sIHDGtVtHtFCGtI
T252-p	HDGtVtHtFCGtIEY
T256-p	VtHtFCGtIEYMAPE
K304	NRKKTIDKILKCKLN
T390	DSKFTRQTPVDsPDD
S394-p	TRQTPVDsPDDSTLS
S403	DDSTLSESANQVFLG
T412-p	NQVFLGFtYVAPSVL
Y413	QVFLGFtYVAPSVLE
S421	VAPSVLESVKEKFsF
S427-p	ESVKEKFsFEPKIRs
S434-p	sFEPKIRsPRRFIGs
S441-p	sPRRFIGsPRtPVsP
T444-p	RFIGsPRtPVsPVKF
S447-p	GsPRtPVsPVKFsPG
S452-p	PVsPVKFsPGDFWGR
T470	ASTANPQTPVEYPME
K516	QAFPMISKRPEHLRM

	rat ► Hide Isoforms
Y11-p	RRRRDGFyPAPDFRH
S40-p	DQPEDAGsEDELEEG
S53	EGGQLNESMDHGGVG
Y62-p	DHGGVGPyELGMEHC
K123	TGKIFAMKVLKKAMI
K126	IFAMKVLKKAMIVRN
R217	HQKGIIYRDLKPENI
S243	DFGLCKESIHDGTVT
T248	KESIHDGTVTHtFCG
T250	SIHDGTVTHtFCGTI
T252-p	HDGTVTHtFCGTIEY
T256	VTHtFCGTIEYMAPE
K304	NRKKTIDKILKCKLN
T390	DSKFTRQTPVDsPDD
S394-p	TRQTPVDsPDDSTLS
S403	DDSTLSESANQVFLG
T412-p	NQVFLGFtYVAPSVL
Y413	QVFLGFtYVAPSVLE
S421	VAPSVLESVKEKFSF
S427	ESVKEKFSFEPKIRs
S434-p	SFEPKIRsPRRFIGs
S441-p	sPRRFIGsPRtPVsP
T444-p	RFIGsPRtPVsPVKF
S447-p	GsPRtPVsPVKFsPG
S452-p	PVsPVKFsPGDFWGR
T470	ASTANPQTPVEYPME
K516	QAFPMISKRPEHLRM

	p70S6K iso2
-	gap
S17-p	DQPEDAGsEDELEEG
S30	EGGQLNESMDHGGVG
Y39	DHGGVGPYELGMEHC
K100	TGKIFAMKVLKKAMI
K103	IFAMKVLKKAMIVRN
R194	HQKGIIYRDLKPENI
S220	DFGLCKESIHDGTVT
T225	KESIHDGTVTHTFCG
T227	SIHDGTVTHTFCGTI
T229	HDGTVTHTFCGTIEY
T233	VTHTFCGTIEYMAPE
K281	NRKKTIDKILKCKLN
T367	DSKFTRQTPVDSPDD
S371	TRQTPVDSPDDSTLS
S380	DDSTLSESANQVFLG
T389-p	NQVFLGFtYVAPSVL
Y390	QVFLGFtYVAPSVLE
S398	VAPSVLESVKEKFSF
S404	ESVKEKFSFEPKIRS
S411	SFEPKIRSPRRFIGS
S418	SPRRFIGSPRtPVsP
T421-p	RFIGSPRtPVsPVKF
S424-p	GSPRtPVsPVKFSPG
S429	PVsPVKFSPGDFWGR
T447	ASTANPQTPVEYPME
K493	QAFPMISKRPEHLRM

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