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IL13
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis |
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Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane
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Molecular Function: interleukin-13 receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity
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Biological Process: positive regulation of connective tissue growth factor production; response to nicotine; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; positive regulation of protein secretion; positive regulation of smooth muscle cell proliferation; positive regulation of B cell proliferation; regulation of proton transport; positive regulation of ion transport; immune response; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of macrophage activation
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Reference #:
P20109 (UniProtKB)
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| Alt. Names/Synonyms: Il-13; Il13; interleukin 13; interleukin-13; T-cell activation protein P600 |
| Gene Symbols: Il13 |
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Molecular weight: 14,108 Da
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Basal Isoelectric point: 8.34
Predict pI for various phosphorylation states
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