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Protein Page:
IL8 (human)

IL8 IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q13-q21
Cellular Component: extracellular space; extracellular region; intracellular
Molecular Function: protein binding; chemokine activity; interleukin-8 receptor binding
Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; unfolded protein response; negative regulation of G-protein coupled receptor protein signaling pathway; neutrophil degranulation; calcium-mediated signaling; chemotaxis; signal transduction; regulation of retroviral genome replication; induction of positive chemotaxis; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cellular protein metabolic process; receptor internalization; response to molecule of bacterial origin; immune response; angiogenesis; cell cycle arrest; cell motility; inflammatory response; embryonic gut development
Reference #:  P10145 (UniProtKB)
Alt. Names/Synonyms: C-X-C motif chemokine 8; CXCL8; emoctakin; GCP-1; granulocyte chemotactic protein 1; IL-8; IL8; Interleukin-8; lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF; MONAP; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; NAP-1; Neutrophil-activating protein 1; Protein 3-10C; small inducible cytokine subfamily B, member 8; T cell chemotactic factor; T-cell chemotactic factor
Gene Symbols: IL8
Molecular weight: 11,098 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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