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Protein Page:
NT-4/5 (human)

Overview
NT-4/5 Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Cytokine; Cell development/differentiation
Cellular Component: endoplasmic reticulum lumen; extracellular region
Molecular Function: growth factor activity
Biological Process: epidermis development; mechanoreceptor differentiation; long-term memory; adult locomotory behavior; sensory organ boundary specification; ganglion mother cell fate determination
Reference #:  P34130 (UniProtKB)
Alt. Names/Synonyms: GLC10; GLC1O; neurotrophin 4; NT4; NTF4; NTF5
Gene Symbols: NTF4
Molecular weight: 22,427 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

NT-4/5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S8-p MLPLPSCsLPILLLF
0 1 - gap
  NT-4/5 iso4  
S8 MLPLPSCSLPILLLF
S114-p RWETTSGsAYVPKTH
  mouse

 
S8 MLPRHSCSLLLFLFL
- gap
  rat

 
S8 MLPRHSCSLLLFLLL
- gap
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