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NT-4/5
Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
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| Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell development/differentiation |
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Cellular Component: endoplasmic reticulum lumen; extracellular region
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Molecular Function: growth factor activity
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Biological Process: epidermis development; mechanoreceptor differentiation; long-term memory; adult locomotory behavior; sensory organ boundary specification; ganglion mother cell fate determination
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Reference #:
P34130 (UniProtKB)
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| Alt. Names/Synonyms: GLC10; GLC1O; neurotrophin 4; NT4; NTF4; NTF5 |
| Gene Symbols: NTF4 |
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Molecular weight: 22,427 Da
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Basal Isoelectric point: 9.01
Predict pI for various phosphorylation states
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