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Protein Page:
Insulin (mouse)

Overview
Insulin Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Hormone
Cellular Component: extracellular space; small nucleolar ribonucleoprotein complex; cytoplasm; extracellular region; intracellular; nucleus; secretory granule
Molecular Function: insulin-like growth factor receptor binding; identical protein binding; protease binding; hormone activity; protein complex binding; insulin receptor binding
Biological Process: activation of MAPK activity; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; activation of NF-kappaB transcription factor; negative regulation of protein oligomerization; positive regulation of glucose import; regulation of protein localization; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; ER overload response; regulation of phosphorylation; positive regulation of mitosis; activation of protein kinase B; negative regulation of acute inflammatory response; myotube differentiation; glucose metabolic process; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; carbohydrate metabolic process; regulation of amino acid metabolic process; negative regulation of protein catabolic process; lipid catabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of cellular protein metabolic process; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; glucose transport; activation of JNK activity; regulation of protein secretion; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; myoblast fusion; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; alpha-beta T cell activation; negative regulation of fatty acid metabolic process; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; regulation of protein binding; fatty acid homeostasis; positive regulation of glycolysis; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of DNA replication; positive regulation of cytokine secretion
Reference #:  P01326 (UniProtKB)
Alt. Names/Synonyms: ins-2; ins2; insulin II; insulin-2
Gene Symbols: Ins2
Molecular weight: 12,364 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Insulin

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 Y108 SLYQLENYCN_____
  human

 
Y108-p SLYQLENyCN_____
  rat

 
Y108 SLYQLENYCN_____
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