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G-CSF (human)

Overview G-CSF Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cytokine; Cell cycle regulation; Secreted, signal peptide; Secreted Cellular Component: extracellular space Molecular Function: enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding Biological Process: granulocyte differentiation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response Reference #:  P09919 (UniProtKB) Alt. Names/Synonyms: C17orf33; colony stimulating factor 3 (granulocyte); CSF3; Filgrastim; G-CSF; GCSF; Granulocyte colony-stimulating factor; Lenograstim; Pluripoietin Gene Symbols: CSF3 Molecular weight: 22,293 Da Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states

Select Structure to View Below G-CSF 1GNC - A=31-207 (human) 1RHG - A/C/B=31-207 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1CD9 1GNC 1PGR 1RHG 2D9Q  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		T6-p	__MAGPAtQSPMKLM

	mouse
A6	__MAQLSAQRRMKLM

	rat
-	gap

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