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Protein Page:
FasL (human)

Overview
FasL Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytokine; Membrane protein, integral
Cellular Component: lysosomal lumen; extracellular space; perinuclear region of cytoplasm; integral to plasma membrane; extracellular region; caveola; nucleus; external side of plasma membrane
Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding
Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; signal transduction; cellular chloride ion homeostasis; endosomal lumen acidification; inflammatory cell apoptosis; negative regulation of angiogenesis; induction of apoptosis via death domain receptors; cell-cell signaling; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptosis; positive regulation of cell proliferation; immune response; retinal cell programmed cell death
Reference #:  P48023 (UniProtKB)
Alt. Names/Synonyms: Apoptosis antigen ligand; APT1LG1; APTL; CD95 ligand; CD95-L; CD95L; Fas antigen ligand; Fas ligand; FASL; FASLG; TNFSF6; Tumor necrosis factor ligand superfamily member 6
Gene Symbols: FASLG
Molecular weight: 31,485 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FasL

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S231-p MMEGKMMsYCtTGQM
0 1 T234-p GKMMsYCtTGQMWAR
  mouse

 
N229 LMEEKRLNYCTTGQI
T232 EKRLNYCTTGQIWAH
  rat

 
N228 LMEEKKLNYCTTGQI
T231 EKKLNYCTTGQIWAH
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