Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TPT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TPT1 a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Microtubule binding protein
Cellular Component: nucleoplasm; multivesicular body; extracellular space; tubulin complex; cytoplasm; nucleus
Molecular Function: protein binding; calcium ion binding; transcription factor binding
Biological Process: cellular calcium ion homeostasis; regulation of apoptosis; calcium ion transport; response to virus; stem cell maintenance; negative regulation of apoptosis
Reference #:  P13693 (UniProtKB)
Alt. Names/Synonyms: FLJ27337; Fortilin; Histamine-releasing factor; HRF; p02; p23; TCTP; TPT1; Translationally-controlled tumor protein; tumor protein, translationally-controlled 1
Gene Symbols: TPT1
Molecular weight: 19,595 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TPT1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K19 EMFSDIYKIREIADG
0 3 K19-ub EMFSDIYkIREIADG
1 14 S46-p TEGNIDDsLIGGNAs
0 2 S53-p sLIGGNAsAEGPEGE
1 0 S64 PEGEGTEStVITGVD
0 1 T65-p EGEGTEStVITGVDI
0 2 Y88-p TSFTKEAyKKyIkDy
0 2 Y91-p TKEAyKKyIkDyMkS
0 1 K93-ac EAyKKyIkDyMkSIK
0 2 Y95-p yKKyIkDyMkSIKGK
0 1 K97-ac KyIkDyMkSIKGKLE
0 2 R107 KGKLEEQRPERVkPF
0 21 K112-ub EQRPERVkPFMTGAA
0 3 K112-ac EQRPERVkPFMTGAA
0 4 Y159-p REDGVTPyMIFFkDG
0 2 K164-ub TPyMIFFkDGLEMEk
0 12 K171-ub kDGLEMEkC______
5251 : Phospho-TCTP (Ser46) Antibody
  mouse

 
K19-ac ELFSDIYkIREIADG
K19-ub ELFSDIYkIREIADG
S46-p TEGAIDDsLIGGNAs
S53-p sLIGGNAsAEGPEGE
S64-p PEGEGTEsTVVTGVD
T65 EGEGTEsTVVTGVDI
Y88 TSFTKEAYKKYIKDY
Y91 TKEAYKKYIKDYMKS
K93 EAYKKYIKDYMKSLK
Y95 YKKYIKDYMKSLKGK
K97 KYIKDYMKSLKGKLE
K107-ub KGKLEEQkPERVkPF
K112-ub EQkPERVkPFMTGAA
K112-ac EQkPERVkPFMTGAA
F159 REDGVTPFMIFFkDG
K164-ub TPFMIFFkDGLEMEK
K171 kDGLEMEKC______
5251 : Phospho-TCTP (Ser46) Antibody
  rat

 
K19-ac ELFSDIYkIREIADG
K19 ELFSDIYKIREIADG
S46 TEGAIDDSLIGGNAS
S53 SLIGGNASAEGPEGE
S64 PEGEGTESTVVTGVD
T65 EGEGTESTVVTGVDI
Y88 TSFTKEAYKKYIkDY
Y91 TKEAYKKYIkDYMkS
K93-ac EAYKKYIkDYMkSLK
Y95 YKKYIkDYMkSLKGK
K97-ac KYIkDYMkSLKGKLE
K107-ub KGKLEEQkPERVkPF
K112 EQkPERVKPFMTGAA
K112-ac EQkPERVkPFMTGAA
F159 REDGVTPFMIFFKDG
K164 TPFMIFFKDGLEMEK
K171 KDGLEMEKC______
5251 : Phospho-TCTP (Ser46) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.