Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
DNMT3L (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Transcription, coactivator/corepressor
Cellular Component: condensed nuclear chromosome; cytoplasm; nuclear heterochromatin; nucleus; cytosol
Molecular Function: transferase activity; methyltransferase activity; protein binding; enzyme binding; metal ion binding; enzyme activator activity
Biological Process: positive regulation of catalytic activity; methylation; in utero embryonic development; negative regulation of transcription, DNA-dependent; placenta development
Reference #:  Q9CWR8 (UniProtKB)
Alt. Names/Synonyms: D6Ertd14e; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; Dnmt3l; ecat7; MGC102308
Gene Symbols: Dnmt3l
Molecular weight: 47,993 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNMT3L

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K12-ub ETPSSCSkTLETLDL
0 2 K45-ub LKSSPALkEDSVDVV
0 1 S61-p EDCKEPLsPSSPPTG
0 1 K199-ub KRWRHQLkAFHDQEG
0 1 K255-ub GSGGGTLkYVEDVTN
0 7 K270-ub VVRRDVEkWGPFDLV
0 2 Y295 CDRCPGWYMFQFHRI
0 2 Y305 QFHRILQYALPRQES
0 1 T340-p TTTRFLQtEAVTLQD
0 9 K376-ub KHAPLTPkEEEYLQA
0 1 K390 AQVRSRSKLDAPkVD
0 3 K390-ub AQVRSRSkLDAPkVD
0 3 K395-ub RSkLDAPkVDLLVKN
  human

 
- gap
- gap
S27 VGSSELSSSVSPGTG
K165 RKWRSQLKAFYDRES
K219 GSDPGQLKHVVDVTD
E234 TVRKDVEEWGPFDLV
Y259-p CDRPPSWyLFQFHRL
Y269-p QFHRLLQyARPKPGS
M304 VASRFLEMEPVTIPD
E340 RHWALVSEEELSLLA
K354-m2 AQNKQSSkLAAKWPT
K354 AQNKQSSKLAAKWPT
W359 SSkLAAKWPTKLVKN
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.