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DNMT3L (mouse)

Overview DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor; Amino Acid Metabolism - cysteine and methionine Cellular Component: condensed nuclear chromosome; cytoplasm; nuclear heterochromatin; nucleus; cytosol Molecular Function: transferase activity; methyltransferase activity; protein binding; enzyme binding; metal ion binding; enzyme activator activity Biological Process: methylation; positive regulation of catalytic activity; in utero embryonic development; negative regulation of transcription, DNA-dependent; placenta development Reference #:  Q9CWR8 (UniProtKB) Alt. Names/Synonyms: D6Ertd14e; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; Dnmt3l; ecat7; MGC102308 Gene Symbols: Dnmt3l Molecular weight: 47,993 Da Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DNMT3L 2PV0 - A/C/B=1-387 (human) 2PVC - A/C/B=1-387 (human) 2QRV - F/C/G/B=160-387 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		K12-u	ETPSSCSkTLETLDL
0	2		K45-u	LKSSPALkEDSVDVV
0	1		S61-p	EDCKEPLsPSSPPTG
0	1		K199-u	KRWRHQLkAFHDQEG
0	1		K255-u	GSGGGTLkYVEDVTN
0	7		K270-u	VVRRDVEkWGPFDLV
0	2		Y295	CDRCPGWYMFQFHRI
0	2		Y305	QFHRILQYALPRQES
0	1		T340-p	TTTRFLQtEAVTLQD
0	9		K376-u	KHAPLTPkEEEYLQA
0	1		K390	AQVRSRSKLDAPkVD
0	3		K390-u	AQVRSRSkLDAPkVD
0	3		K395-u	RSkLDAPkVDLLVKN

	human
-	gap
-	gap
S27	VGSSELSSSVSPGTG
K165	RKWRSQLKAFYDRES
K219	GSDPGQLKHVVDVTD
E234	TVRKDVEEWGPFDLV
Y259-p	CDRPPSWyLFQFHRL
Y269-p	QFHRLLQyARPKPGS
-	under review
E340	RHWALVSEEELSLLA
K354-m2	AQNKQSSkLAAKWPT
K354	AQNKQSSKLAAKWPT
W359	SSkLAAKWPTKLVKN

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