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Protein Page:
DNMT3L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Amino Acid Metabolism - cysteine and methionine
Cellular Component: condensed nuclear chromosome; nuclear heterochromatin; nucleus; cytosol
Molecular Function: protein binding; enzyme binding; metal ion binding; enzyme activator activity
Biological Process: positive regulation of catalytic activity; genetic imprinting; in utero embryonic development; DNA methylation; spermatogenesis; negative regulation of transcription, DNA-dependent; placenta development
Reference #:  Q9UJW3 (UniProtKB)
Alt. Names/Synonyms: cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; DNMT3L; human cytosine-5-methyltransferase 3-like protein; MGC1090
Gene Symbols: DNMT3L
Molecular weight: 43,583 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Select Structure to View Below

DNMT3L

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 2 - gap
0 1 S27 VGSSELSSSVSPGTG
0 1 K165 RKWRSQLKAFYDRES
0 1 K219 GSDPGQLKHVVDVTD
0 7 E234 TVRKDVEEWGPFDLV
0 2 Y259-p CDRPPSWyLFQFHRL
0 2 Y269-p QFHRLLQyARPKPGS
0 1 M304 VASRFLEMEPVTIPD
0 9 E340 RHWALVSEEELSLLA
0 1 K354-m2 AQNKQSSkLAAKWPT
0 3 K354 AQNKQSSKLAAKWPT
0 3 W359 SSkLAAKWPTKLVKN
  mouse

 
K12-ub ETPSSCSkTLETLDL
K45-ub LKSSPALkEDSVDVV
S61-p EDCKEPLsPSSPPTG
K199-ub KRWRHQLkAFHDQEG
K255-ub GSGGGTLkYVEDVTN
K270-ub VVRRDVEkWGPFDLV
Y295 CDRCPGWYMFQFHRI
Y305 QFHRILQYALPRQES
T340-p TTTRFLQtEAVTLQD
K376-ub KHAPLTPkEEEYLQA
K390 AQVRSRSKLDAPkVD
K390-ub AQVRSRSkLDAPkVD
K395-ub RSkLDAPkVDLLVKN
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