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DNMT3L (human)

Overview DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Amino Acid Metabolism - cysteine and methionine; Transcription, coactivator/corepressor Cellular Component: condensed nuclear chromosome; nuclear heterochromatin; cytosol; nucleus Molecular Function: protein binding; enzyme binding; metal ion binding; enzyme activator activity Biological Process: genetic imprinting; in utero embryonic development; DNA methylation; spermatogenesis; negative regulation of transcription, DNA-dependent Reference #:  Q9UJW3 (UniProtKB) Alt. Names/Synonyms: cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; DNMT3L; human cytosine-5-methyltransferase 3-like protein; MGC1090 Gene Symbols: DNMT3L Molecular weight: 43,583 Da Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states

Select Structure to View Below DNMT3L 2PV0 - A/C/B=1-387 (human) 2PVC - A/C/B=1-387 (human) 2QRV - F/C/G/B=160-387 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2PV0 2PVC 2QRV  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	2		-	gap
0	1		S27	VGSSELSSSVSPGTG
0	1		K165	RKWRSQLKAFYDRES
0	1		K219	GSDPGQLKHVVDVTD
0	7		E234	TVRKDVEEWGPFDLV
0	2		Y259-p	CDRPPSWyLFQFHRL
0	2		Y269-p	QFHRLLQyARPKPGS
0	1		-	under review
0	9		E340	RHWALVSEEELSLLA
0	1		K354-m2	AQNKQSSkLAAKWPT
0	3		K354	AQNKQSSKLAAKWPT
0	3		W359	SSkLAAKWPTKLVKN

	mouse
K12-u	ETPSSCSkTLETLDL
K45-u	LKSSPALkEDSVDVV
S61-p	EDCKEPLsPSSPPTG
K199-u	KRWRHQLkAFHDQEG
K255-u	GSGGGTLkYVEDVTN
K270-u	VVRRDVEkWGPFDLV
Y295	CDRCPGWYMFQFHRI
Y305	QFHRILQYALPRQES
T340-p	TTTRFLQtEAVTLQD
K376-u	KHAPLTPkEEEYLQA
K390	AQVRSRSKLDAPkVD
K390-u	AQVRSRSkLDAPkVD
K395-u	RSkLDAPkVDLLVKN

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