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LRP5
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1. Widely expressed, with the highest level of expression in the liver and in aorta. Belongs to the LDLR family. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, misc.; Membrane protein, integral |
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Cellular Component: endoplasmic reticulum; integral to membrane; plasma membrane; receptor complex
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Molecular Function: Wnt-protein binding; Wnt receptor activity; protein binding; toxin transporter activity; coreceptor activity
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Biological Process: Wnt receptor signaling pathway; positive regulation of mitosis; positive regulation of transcription, DNA-dependent; endocytosis; Wnt receptor signaling pathway through beta-catenin; gastrulation with mouth forming second; bone remodeling; osteoblast development; anterior/posterior pattern formation; bone marrow development; glucose catabolic process; cholesterol homeostasis; regulation of blood pressure; embryonic retina morphogenesis in camera-type eye; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of fat cell differentiation; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; retina morphogenesis in camera-type eye; embryonic limb morphogenesis
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Reference #:
O75197 (UniProtKB)
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| Alt. Names/Synonyms: BMND1; EVR1; EVR4; HBM; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; LR3; LRP-5; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2 |
| Gene Symbols: LRP5 |
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Molecular weight: 179,145 Da
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Basal Isoelectric point: 5.11
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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mTOR Signaling
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Regulation of Microtubule Dynamics
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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