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Protein Page:
SNCA (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; terminal button; inclusion body; cytosol; synaptic vesicle; platelet alpha granule membrane; perinuclear region of cytoplasm; cytoplasm; synapse; cytoplasmic vesicle membrane; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; cell cortex; actin cytoskeleton; cytoskeleton; growth cone; axon; plasma membrane; ribosome; nerve terminal; nucleus
Molecular Function: identical protein binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; metal ion binding; magnesium ion binding; calcium ion binding; oxidoreductase activity; Hsp70 protein binding; enzyme binding; phospholipase binding; phospholipid binding; alpha-tubulin binding; protein domain specific binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; tau protein binding
Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of neuronal synaptic plasticity; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of dopamine uptake; negative regulation of histone acetylation; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; regulation of macrophage activation; negative regulation of microtubule polymerization; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
Reference #:  O55042 (UniProtKB)
Alt. Names/Synonyms: alpha SYN; Alpha-synuclein; alphaSYN; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Snca; Syn; synuclein, alpha; SYUA
Gene Symbols: Snca
Molecular weight: 14,485 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SNCA

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S129‑p
protein stabilization: S129‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K6-u __MDVFMkGLSKAKE
1 0 K6 __MDVFMKGLSKAKE
1 0 K10 VFMkGLSKAKEGVVA
0 1 K12 MkGLSKAKEGVVAAA
1 0 K12 MkGLSKAKEGVVAAA
0 1 K21 GVVAAAEKTKQGVAE
1 0 K21 GVVAAAEKTKQGVAE
0 3 K23 VAAAEKTKQGVAEAA
1 0 K23 VAAAEKTKQGVAEAA
1 0 K34 AEAAGKTKEGVLyVG
1 12 Y39-p KTKEGVLyVGSKTKE
0 2 K43 GVLyVGSKTKEGVVH
1 0 K45 LyVGSKTKEGVVHGV
0 1 T54-gl GVVHGVTtVAEKtKE
0 1 T54 GVVHGVTTVAEKtKE
0 1 T59-gl VTtVAEKtKEQVTNV
1 0 K60 TtVAEKtKEQVTNVG
1 1 T72-gl NVGGAVVtGVTAVAQ
1 0 K80 GVTAVAQKTVEGAGN
4 0 N87 KTVEGAGNIAAATGF
0 1 N87 KTVEGAGNIAAATGF
0 1 K96-u AAATGFVkKDQMGKG
2 0 K96 AAATGFVKKDQMGKG
2 0 K102 VkKDQMGKGEEGYPQ
5 0 Y125 VDPGSEAYEMPsEEG
32 3 S129-p SEAYEMPsEEGYQDY
2 0 Y133 EMPsEEGYQDYEPEA
2 0 Y136 sEEGYQDYEPEA___
  human

 
K6 __MDVFMKGLSkAkE
K6-s __MDVFMkGLSkAkE
K10-s VFMkGLSkAkEGVVA
K12-u MkGLSkAkEGVVAAA
K12-s MkGLSkAkEGVVAAA
K21-u GVVAAAEkTkQGVAE
K21-s GVVAAAEkTkQGVAE
K23-u VAAAEkTkQGVAEAA
K23-s VAAAEkTkQGVAEAA
K34-s AEAAGKTkEGVLyVG
Y39-p KTkEGVLyVGSKTkE
K43 GVLyVGSKTkEGVVH
K45-s LyVGSKTkEGVVHGV
T54 GVVHGVATVAEKTkE
T54-ga GVVHGVAtVAEKTkE
T59 VAtVAEKTkEQVTNV
K60-s AtVAEKTkEQVTNVG
T72 NVGGAVVTGVTAVAQ
K80-s GVTAVAQkTVEGAGs
S87-p kTVEGAGsIAAATGF
S87-gl kTVEGAGsIAAATGF
K96 AAATGFVKKDQLGkN
K96-s AAATGFVkKDQLGkN
K102-s VkKDQLGkNEEGAPQ
Y125-p VDPDNEAyEMPsEEG
S129-p NEAyEMPsEEGyQDy
Y133-p EMPsEEGyQDyEPEA
Y136-p sEEGyQDyEPEA___
  rat

 
K6 __MDVFMKGLSKAKE
K6 __MDVFMKGLSKAKE
K10 VFMKGLSKAKEGVVA
K12 MKGLSKAKEGVVAAA
K12 MKGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39-p KTKEGVLyVGSkTKE
K43-u GVLyVGSkTKEGVVH
K45 LyVGSkTKEGVVHGV
T54 GVVHGVTTVAEKTKE
T54 GVVHGVTTVAEKTKE
T59 VTTVAEKTKEQVTNV
K60 TTVAEKTKEQVTNVG
T72-gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VKKDQMGKGEEGYPQ
Y125 VDPSSEAYEMPSEEG
S129 SEAYEMPSEEGYQDY
Y133 EMPSEEGYQDYEPEA
Y136 SEEGYQDYEPEA___
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