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SNCA
a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
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Cellular Component: Golgi apparatus; nuclear outer membrane; cytoplasmic vesicle membrane; mitochondrion; rough endoplasmic reticulum; intracellular membrane-bound organelle; fibril; terminal button; cell cortex; inclusion body; cytosol; actin cytoskeleton; synaptic vesicle; cytoskeleton; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; synapse; nerve terminal; nucleus
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Molecular Function: identical protein binding; protein domain specific binding; histone binding; zinc ion binding; kinesin binding; metal ion binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; magnesium ion binding; protein N-terminus binding; phosphoprotein binding; Hsp70 protein binding; calcium ion binding; oxidoreductase activity; arachidonic acid binding; dynein binding; enzyme binding; phospholipase binding; copper ion binding; phospholipid binding; tau protein binding; alpha-tubulin binding
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Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; membrane organization and biogenesis; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of neuronal synaptic plasticity; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of caspase activity; negative regulation of monooxygenase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of histone acetylation; negative regulation of dopamine uptake; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
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Reference #:
O55042 (UniProtKB)
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| Alt. Names/Synonyms: alpha SYN; Alpha-synuclein; alphaSYN; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Snca; Syn; synuclein, alpha; SYUA |
| Gene Symbols: Snca |
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Molecular weight: 14,485 Da
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Basal Isoelectric point: 4.74
Predict pI for various phosphorylation states
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CST Pathways:
Parkinson's Disease
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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