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CP110 (human)

Overview CP110 Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: centriole; centrosome; cytosol Molecular Function: protein binding Biological Process: centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis; centrosome duplication Reference #:  O43303 (UniProtKB) Alt. Names/Synonyms: 9738; CE110; Centrosomal protein of 110 kDa; CEP110; CP110; CP110 protein; DKFZp781G1416; KIAA0419 Gene Symbols: CCP110 Molecular weight: 113,424 Da Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CP110

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		N49	AILSPLLNIEKRKEM
0	1		T107-p	FDQWEMEtVySNSEV
0	96		Y109-p	QWEMEtVySNSEVRN
0	2		S170-p	RDSEGFNsPKQCDSS
0	1		T194	FPKTSSATPQETLIS
0	14		S247-p	EREQSRRsLRGsINR
0	2		S251-p	SRRsLRGsINRIVNE
0	1		S259-p	INRIVNEsHLDKEHD
0	4		S366-p	GSYAKLPsPEPsMsP
0	2		S370-p	KLPsPEPsMsPKMHR
0	5		S372-p	PsPEPsMsPKMHRRR
0	1		S380-p	PKMHRRRsRtssACH
0	8		T382-p	MHRRRsRtssACHIL
0	2		S383-p	HRRRsRtssACHILI
0	6		S384-p	RRRsRtssACHILIN
0	25		S400-p	PINACELsPKGKEQA
0	1		Y441-p	GVCSSKVyVGKNTSE
0	3		Y508-p	MPKLHEPyASSQCIA
0	1		S516-p	ASSQCIAsPNFGTVS
0	2		S551-p	SYDVKNPsPLLMQNQ
0	4		Y602-p	LQKENCPyVITSGIT
0	1		Y621	QHLPEKRYPKGsGFV
0	1		S625-p	EKRYPKGsGFVNkNK
0	1		K630-u	KGsGFVNkNKMLGTS
0	1		K639-u	KMLGTSSkEsEELLK
0	1		S641-p	LGTSSkEsEELLKSK
0	14		S788-p	GRAKTRWsQVFsLEI
0	1		S792-p	TRWsQVFsLEIQAKF
0	1		S854-p	IVSAQDAsLQERVLA
0	2		T915	RVALSAATQKSLDRK
0	1		K922	TQKSLDRKKYMKAAE
0	1		K923	QKSLDRKKYMKAAEM
0	2		S995-p	VPNRVPVsGVyAGKI
0	68		Y998-p	RVPVsGVyAGKIQRK

	mouse
T49-p	AVLSPLLtIEKRKKI
T107	FDQWATETIYSNPEV
Y109	QWATETIYSNPEVTD
-	under review
S194-p	ALRLSSAsPQETIIS
S245	ERELSSRSLRNSLKR
S249	SSRSLRNSLKRSVNE
T257	LKRSVNETHSDREND
S364-p	GPYAKLPsPEPsMsP
S368-p	KLPsPEPsMsPTMHR
S370-p	PsPEPsMsPTMHRRH
S378	PTMHRRHSRsAsACQ
S380-p	MHRRHSRsAsACQIL
A381	HRRHSRsAsACQILI
S382-p	RRHSRsAsACQILIN
S398-p	PVNACELsPKGKEEA
S439	GVCSSNVSATKITSE
Q506	VPKLHELQPSSQCVS
-	under review
S550	SYDVKHPSPLLTQTQ
Y601	LQKENCPYIITAGVA
Y620-p	DRLLERRyPKGFVHI
F624	ERRyPKGFVHINKNK
K629	KGFVHINKNKMLETS
K638	KMLETSPKEGQELLK
G640	LETSPKEGQELLKSK
S780	GRAQAKWSQVFNPEI
N784	AKWSQVFNPEIHAKF
S846	VVSAQDASLQERVLA
T907-p	RVALSVAtQKSLDRk
K914-a	tQKSLDRkkFMKVAE
K915-a	QKSLDRkkFMKVAEM
S987	VPNRAPVSGAYAGKT
Y990	RAPVSGAYAGKTQRK

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