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ZO3 (human)

Overview ZO3 Interacts with occludin, claudins and ZO-1. Interacts with INADL. Interacts with UBN1. Interacts with FASLG. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion Cellular Component: tight junction; apical plasma membrane; nucleus Molecular Function: protein binding Reference #:  O95049 (UniProtKB) Alt. Names/Synonyms: MGC119546; Tight junction protein 3; tight junction protein 3 (zona occludens 3); Tight junction protein ZO-3; TJP3; ZO-3; ZO3; zona occludens 3; Zona occludens protein 3; Zonula occludens protein 3 Gene Symbols: TJP3 Molecular weight: 102,800 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ZO3 3KFV - A=489-789 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S106-p	ATKASPSsPGRQDsD
0	12		S112-p	SsPGRQDsDEDDGPQ
0	1		S134-p	GRGYDGDssSGSGRS
0	1		S135-p	RGYDGDssSGSGRSW
0	4		S159-p	GRRGRAGsHGRRsPG
0	15		S164-p	AGsHGRRsPGGGsEA
0	3		P165	GsHGRRsPGGGsEAN
0	4		S169-p	RRsPGGGsEANGLAL
0	1		K194	DVQMKPVKSVLVKRR
0	13		S203-p	VLVKRRDsEEFGVKL
0	2		S212-p	EFGVKLGsQIFIKHI
0	24		S333-p	PPRHAQRsPEAsQtD
0	5		S337-p	AQRsPEAsQtDsPVE
0	3		T339-p	RsPEAsQtDsPVESP
0	14		S341-p	PEAsQtDsPVESPRL
0	2		S345	QtDsPVESPRLRREs
0	14		S352-p	SPRLRREssVDsRtI
0	13		S353-p	PRLRREssVDsRtIs
0	7		S356-p	RREssVDsRtIsEPD
0	2		T358-p	EssVDsRtIsEPDEQ
0	21		S360-p	sVDsRtIsEPDEQRS
0	21		L369	PDEQRSELPRESsYD
0	2		S374-p	SELPRESsYDIyRVP
0	36		Y378-p	RESsYDIyRVPssQs
0	108		S382-p	YDIyRVPssQsMEDR
0	39		S383-p	DIyRVPssQsMEDRG
0	86		S385-p	yRVPssQsMEDRGYs
0	1		Y391	QsMEDRGYsPDTRVV
0	10		S392-p	sMEDRGYsPDTRVVR
0	2		Y493-p	SRVGDSFyIRTHFEL
0	3		S578-p	AVGVGPGsSAGSNAR
0	3		S605-p	AKKTTQRsREDLSAL
0	1		K674	DSPSKIIKLDTVRVI
0	16		T693-p	KHALLDVtPsAIERL
0	1		S695-p	ALLDVtPsAIERLNY
0	12		S870-p	VQADESQsPRDRGRI
0	13		S898-p	QGQWRQDsMRTYERE
0	6		S919-p	MRVHDAEssDEDGYD
0	6		S920-p	RVHDAEssDEDGYDW

	mouse
S106-p	ATKASPAsGHQLsDQ
S111-p	PAsGHQLsDQEEADH
S126	GRGYEGDSSSGSGRS
S127	RGYEGDSSSGSGRSW
S151-p	GRRGRVGsHGRRssG
S156-p	VGsHGRRssGGGsEA
S157-p	GsHGRRssGGGsEAN
S161-p	RRssGGGsEANGLDL
K186-u	DVLMRPLkSVLVKRR
S195-p	VLVKRRNsEEFGVKL
S204-p	EFGVKLGsQIFIKHI
S311-p	PPLKGQRsPEDsQtD
S315-p	GQRsPEDsQtDsPVE
T317-p	RsPEDsQtDsPVEtP
S319-p	PEDsQtDsPVEtPQP
T323-p	QtDsPVEtPQPRRRE
R331	PQPRRRERSVNSRAI
S332	QPRRRERSVNSRAIA
S335	RRERSVNSRAIAEPE
A337	ERSVNSRAIAEPEsP
A339	SVNSRAIAEPEsPGE
S343-p	RAIAEPEsPGESRYD
R348	PEsPGESRYDIYRVP
Y352	GESRYDIYRVPsRQs
S356-p	YDIYRVPsRQsLEDR
R357	DIYRVPsRQsLEDRG
S359-p	YRVPsRQsLEDRGys
Y365-p	QsLEDRGysPDTRVV
S366-p	sLEDRGysPDTRVVS
Y468	SRVGDSFYIRTHFEL
A556	AAGVGPGASVGSNPR
S584-p	KKASTQRsREDLSAL
K653-u	DSPSKIIkLDTVRVI
T672-p	KHALLDVtPSAIERL
S674	ALLDVtPSAIERLNY
G841	VWVDDHQGLMGHGTT
S870	QDQRRQDSMRTYKHE
S891-p	TRARDVEssDDEGYD
S892-p	RARDVEssDDEGYDW

	rat
S111	ATKASPASGHQLsDQ
S116-p	PASGHQLsDQEEADH
S131	GRGYEGDSSSGSGRS
S132	RGYEGDSSSGSGRSW
S156	GRRVRMGSHGRRSSC
S161	MGSHGRRSSCGGSEA
S162	GSHGRRSSCGGSEAN
S166	RRSSCGGSEANGLDL
K191	DVLMRPLKSVLVKRR
S200-p	VLVKRRNsEEFGVKL
S209	EFGVKLGSQIFIKHI
S316	PPLKSRRSPEDSQTD
S320	SRRSPEDSQTDSPVE
T322	RSPEDSQTDSPVETP
S324	PEDSQTDSPVETPQP
T328	QTDSPVETPQPQRRE
R336	PQPQRRERSVDSRAI
S337	QPQRRERSVDSRAIA
S340	RRERSVDSRAIAEPE
A342	ERSVDSRAIAEPEsP
A344	SVDSRAIAEPEsPGE
S348-p	RAIAEPEsPGESRYD
R353	PEsPGESRYDIYRVP
Y357	GESRYDIYRVPsRQs
S361-p	YDIYRVPsRQsLEDR
R362	DIYRVPsRQsLEDRG
S364-p	YRVPsRQsLEDRGYS
Y370	QsLEDRGYSPDTRVV
S371	sLEDRGYSPDTRVVR
Y472	SRVGDSFYIRTHFEL
A560	AAGLGPGASTGSNPR
S588	KKTMTQRSREDLSAL
K657	DSPSKIIKLDTVRVI
T676-p	KHALLDVtPSAIERL
S678	ALLDVtPSAIERLNY
G845	VWVDDHQGLMGHGRI
S872	PDQRRQDSMRTYKHE
S893	TRARDIESSDEEGYD
S894	RARDIESSDEEGYDW

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