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Protein Page:
ZO3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZO3 Interacts with occludin, claudins and ZO-1. Interacts with INADL. Interacts with UBN1. Interacts with FASLG. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Cellular Component: tight junction; apical plasma membrane; nucleus
Molecular Function: protein binding
Reference #:  O95049 (UniProtKB)
Alt. Names/Synonyms: MGC119546; Tight junction protein 3; tight junction protein 3 (zona occludens 3); Tight junction protein ZO-3; TJP3; ZO-3; ZO3; zona occludens 3; Zona occludens protein 3; Zonula occludens protein 3
Gene Symbols: TJP3
Molecular weight: 101,397 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZO3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S103-p HLPATKAsPSsPGRQ
0 3 S106-p ATKAsPSsPGRQDsD
0 15 S112-p SsPGRQDsDEDDGPQ
0 1 Y130-p EVDQGRGyDGDsssG
0 1 S134-p GRGyDGDsssGsGRS
0 1 S135-p RGyDGDsssGsGRSW
0 1 S136-p GyDGDsssGsGRSWD
0 1 S138-p DGDsssGsGRSWDER
0 4 S159-p GRRGRAGsHGRRsPG
0 18 S164-p AGsHGRRsPGGGsEA
0 4 P165 GsHGRRsPGGGsEAN
0 6 S169-p RRsPGGGsEANGLAL
0 1 K194 DVQMKPVKSVLVKRR
0 16 S203-p VLVKRRDsEEFGVKL
0 3 S212-p EFGVKLGsQIFIKHI
0 27 S319-p PPRHAQRsPEAsQtD
0 6 S323-p AQRsPEAsQtDsPVE
0 4 T325-p RsPEAsQtDsPVEsP
0 15 S327-p PEAsQtDsPVEsPRL
0 3 S331-p QtDsPVEsPRLRREs
0 14 S338-p sPRLRREssVDsRtI
0 13 S339-p PRLRREssVDsRtIs
0 7 S342-p RREssVDsRtIsEPD
0 2 T344-p EssVDsRtIsEPDEQ
0 25 S346-p sVDsRtIsEPDEQRS
0 22 L355 PDEQRSELPRESsYD
0 2 S360-p SELPRESsYDIyRVP
0 40 Y364-p RESsYDIyRVPssQs
0 112 S368-p YDIyRVPssQsMEDR
0 40 S369-p DIyRVPssQsMEDRG
0 88 S371-p yRVPssQsMEDRGYs
0 1 Y377 QsMEDRGYsPDTRVV
0 11 S378-p sMEDRGYsPDTRVVR
0 1 S489-p THFELEPsPPSGLGF
0 1 R518-m1 GPGQSHArGGHWLAV
0 3 S564-p AVGVGPGsSAGSNAR
0 5 S591-p AKKTTQRsREDLSAL
0 1 T599-p REDLSALtRQGRYPP
0 1 K660 DSPSKIIKLDTVRVI
0 14 T679-p KHALLDVtPsAIERL
0 1 S681-p ALLDVtPsAIERLNY
0 1 S805 SCDSRVNSDYETDGE
0 1 T809 RVNSDYETDGEGGAY
0 13 S856-p VQADESQsPRDRGRI
0 13 S884-p QGQWRQDsMRTYERE
0 8 S905-p MRVHDAEssDEDGYD
0 8 S906-p RVHDAEssDEDGYDW
  mouse

 
S103-p QLPATKAsPAsGHQL
S106-p ATKAsPAsGHQLsDQ
S111-p PAsGHQLsDQEEADH
Y122 EADHGRGYEGDSSSG
S126 GRGYEGDSSSGSGRS
S127 RGYEGDSSSGSGRSW
S128 GYEGDSSSGSGRSWG
S130 EGDSSSGSGRSWGER
S151-p GRRGRVGsHGRRssG
S156-p VGsHGRRssGGGsEA
S157-p GsHGRRssGGGsEAN
S161-p RRssGGGsEANGLDL
K186-ub DVLMRPLkSVLVKRR
S195-p VLVKRRNsEEFGVKL
S204-p EFGVKLGsQIFIKHI
S311-p PPLKGQRsPEDsQtD
S315-p GQRsPEDsQtDsPVE
T317-p RsPEDsQtDsPVEtP
S319-p PEDsQtDsPVEtPQP
T323-p QtDsPVEtPQPRRRE
R331 PQPRRRERSVNSRAI
S332 QPRRRERSVNSRAIA
S335 RRERSVNSRAIAEPE
A337 ERSVNSRAIAEPEsP
A339 SVNSRAIAEPEsPGE
S343-p RAIAEPEsPGESRYD
R348 PEsPGESRYDIYRVP
Y352 GESRYDIYRVPsRQs
S356-p YDIYRVPsRQsLEDR
R357 DIYRVPsRQsLEDRG
S359-p YRVPsRQsLEDRGys
Y365-p QsLEDRGysPDTRVV
S366-p sLEDRGysPDTRVVS
S478 THFELEPSPPYGLGF
H510 PGHGHSSHGGLWLAA
A556 AAGVGPGASVGSNPR
S584-p KKASTQRsREDLSAL
T592 REDLSALTRQGHYPP
K653-ub DSPSKIIkLDTVRVI
T672-p KHALLDVtPSAIERL
S674 ALLDVtPSAIERLNY
S797-p SCDSRTNsDYEDtDG
T802-p TNsDYEDtDGEGAYT
G841 VWVDDHQGLMGHGTT
S870-p QDQRRQDsMRTYKHE
S891-p TRARDVEssDDEGYD
S892-p RARDVEssDDEGYDW
  rat

 
S108 QLPATKASPASGHQL
S111 ATKASPASGHQLsDQ
S116-p PASGHQLsDQEEADH
Y127 EADHGRGYEGDSSSG
S131 GRGYEGDSSSGSGRS
S132 RGYEGDSSSGSGRSW
S133 GYEGDSSSGSGRSWG
S135 EGDSSSGSGRSWGER
S156 GRRVRMGSHGRRSSC
S161 MGSHGRRSSCGGSEA
S162 GSHGRRSSCGGSEAN
S166 RRSSCGGSEANGLDL
K191 DVLMRPLKSVLVKRR
S200-p VLVKRRNsEEFGVKL
S209 EFGVKLGSQIFIKHI
S316 PPLKSRRSPEDSQTD
S320 SRRSPEDSQTDSPVE
T322 RSPEDSQTDSPVETP
S324 PEDSQTDSPVETPQP
T328 QTDSPVETPQPQRRE
R336 PQPQRRERSVDSRAI
S337 QPQRRERSVDSRAIA
S340 RRERSVDSRAIAEPE
A342 ERSVDSRAIAEPEsP
A344 SVDSRAIAEPEsPGE
S348-p RAIAEPEsPGESRYD
R353 PEsPGESRYDIYRVP
Y357 GESRYDIYRVPsRQs
S361-p YDIYRVPsRQsLEDR
R362 DIYRVPsRQsLEDRG
S364-p YRVPsRQsLEDRGYS
Y370 QsLEDRGYSPDTRVV
S371 sLEDRGYSPDTRVVR
S482 THFELEPSPPYGLGF
H514 SGHGHSSHGGLWLAA
A560 AAGLGPGASTGSNPR
S588 KKTMTQRSREDLSAL
T596 REDLSALTRQGHYPP
K657 DSPSKIIKLDTVRVI
T676-p KHALLDVtPSAIERL
S678 ALLDVtPSAIERLNY
S801 SCDSRANSDYEDTDG
T806 ANSDYEDTDGEGTYT
G845 VWVDDHQGLMGHGRI
S872 PDQRRQDSMRTYKHE
S893 TRARDIESSDEEGYD
S894 RARDIESSDEEGYDW
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