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Protein Page:
ATP2A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP2A1 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Hydrolase; Endoplasmic reticulum; EC 3.6.3.8; Membrane protein, integral; Transporter, ion channel
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: I band; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; ER-Golgi intermediate compartment; integral to membrane
Molecular Function: protein binding; protein homodimerization activity; calcium-transporting ATPase activity; calcium ion binding; ATP binding
Biological Process: ATP catabolic process; metabolic process; positive regulation of fast-twitch skeletal muscle contraction; maintenance of mitochondrion localization; elevation of endoplasmic reticulum calcium ion concentration; regulation of striated muscle contraction; elevation of mitochondrial calcium ion concentration; negative regulation of striated muscle contraction; apoptotic mitochondrial changes; calcium ion transport; reduction of endoplasmic reticulum calcium ion concentration; blood coagulation; transmembrane transport
Reference #:  O14983 (UniProtKB)
Alt. Names/Synonyms: AT2A1; ATP2A; ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATPase, Ca++ transporting, fast twitch 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1
Gene Symbols: ATP2A1
Molecular weight: 110,252 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATP2A1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S186‑p
molecular association, regulation: S186‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K7 _MEAAHAKTTEECLA
0 1 S19-p CLAYFGVsETTGLTP
0 1 K30 GLTPDQVKRNLEKYG
0 2 K35 QVKRNLEKYGLNELP
0 3 K120-ub ENAIEALkEYEPEMG
0 2 K128-ub EYEPEMGkVYRADRK
0 1 R131 PEMGkVYRADRKSVQ
0 1 R131 PEMGkVYRADRKSVQ
0 1 R134 GkVYRADRKSVQRIK
0 1 R139 ADRKSVQRIKARDIV
0 1 K169 DIRILAIKsTTLRVD
0 1 S170-p IRILAIKsTTLRVDQ
1 1 S186-p ILTGESVsVIKHTEP
0 1 K218-ac GTNIAAGkALGIVAT
0 1 K234 GVGTEIGKIRDQMAA
0 1 K246 MAATEQDKTPLQQkL
0 2 K252-ub DKTPLQQkLDEFGEQ
0 2 K328-ub LGTRRMAkkNAIVRs
0 1 K329-ub GTRRMAkkNAIVRsL
0 1 S335-p kkNAIVRsLPSVETL
0 1 K436 EAKGVYEKVGEATET
0 1 S473-p ERANACNsVIRQLMK
0 4 T484-p QLMKKEFtLEFsRDR
0 1 S488-p KEFtLEFsRDRkSMS
0 1 K492-ac LEFsRDRkSMSVyCS
0 2 K492 LEFsRDRKSMSVyCS
0 4 Y497-p DRkSMSVyCSPAKSS
0 2 K502 SVyCSPAKSSRAAVG
0 1 K511 SRAAVGNKMFVkGAP
0 3 K515-ub VGNKMFVkGAPEGVI
0 44 Y527-p GVIDRCNyVRVGTTR
0 1 T532 CNyVRVGTTRVPLTG
0 1 K542 VPLTGPVKEKIMAVI
0 1 K544 LTGPVKEKIMAVIKE
0 1 A547 PVKEKIMAVIKEWGT
0 1 K550 EKIMAVIKEWGTGRD
0 1 K572 ATRDTPPKREEMVLD
0 1 S581-p EEMVLDDsARFLEYE
0 1 K605 GMLDPPRKEVtGSIQ
0 1 T608-p DPPRKEVtGSIQLCR
0 1 T625-p GIRVIMItGDNKGTA
0 1 K629 IMItGDNKGTAIAIC
0 1 G643 CRRIGIFGENEEVAD
0 1 K712 VNDAPALKkAEIGIA
0 2 K713-ub NDAPALKkAEIGIAM
0 1 S722-p EIGIAMGsGtAVAKT
0 1 T724-p GIAMGsGtAVAKTAs
0 1 S731-p tAVAKTAsEMVLADD
0 4 K758-ub RAIYNNMkQFIRYLI
  mouse

 
K7-ub _MEAAHSkSTEECLS
S19 CLSYFGVSETTGLTP
K30-ub GLTPDQVkRHLEkYG
K35-ub QVkRHLEkYGPNELP
K120-ub ENAIEALkEYEPEMG
K128-ub EYEPEMGkVYrADRK
R131 PEMGkVYRADRKSVQ
R131-m2 PEMGkVYrADRKSVQ
R134 GkVYrADRKSVQrIK
R139-m2 ADRKSVQrIKARDIV
K169-ub DIRILSIkSTTLRVD
S170 IRILSIkSTTLRVDQ
S186-p ILTGESVsVIKHTDP
K218 GTNIAAGKAVGIVAT
K234-ub GVSTEIGkIRDQMAA
K246-ub MAATEQDkTPLQQKL
K252 DkTPLQQKLDEFGEQ
K328-ub LGTRRMAkKNAIVRS
K329 GTRRMAkKNAIVRSL
S335 kKNAIVRSLPSVETL
K436-ub ETKGVYEkVGEATET
S473 ERANACNSVIRQLMK
T484-p QLMKKEFtLEFSRDR
S488 KEFtLEFSRDRkSMS
K492 LEFSRDRKSMSVYCS
K492-ub LEFSRDRkSMSVYCS
Y497 DRkSMSVYCSPAkSS
K502-ub SVYCSPAkSSRAAVG
K511-ub SRAAVGNkMFVkGAP
K515-ub VGNkMFVkGAPEGVI
Y527-p GVIDRCNyVRVGtTR
T532-p CNyVRVGtTRVPLTG
K542-ub VPLTGPVkEkIMsVI
K544-ub LTGPVkEkIMsVIkE
S547-p PVkEkIMsVIkEWGT
K550-ub EkIMsVIkEWGTGRD
K572-ub ATRDTPPkREEMVLD
S581 EEMVLDDSAKFMEYE
K605-ub GMLDPPRkEVTGSIQ
T608 DPPRkEVTGSIQLCR
T625 GIRVIMITGDNkGTA
K629-ub IMITGDNkGTAIAIC
S643-p CRRIGIFsENEEVTD
K712-ub VNDAPALkkAEIGIA
K713-ub NDAPALkkAEIGIAM
S722 EIGIAMGSGtAVAKT
T724-p GIAMGSGtAVAKTAS
S731 tAVAKTASEMVLADD
K758-ub RAIYNNMkQFIRYLI
  rat

 
K7 _MEAAHSKSTEECLS
S19 CLSYFGVSETTGLTP
K30 GLTPDQVKRHLEKYG
K35 QVKRHLEKYGPNELP
K120 ENAIEALKEYEPEMG
K128 EYEPEMGKVYrADrK
R131-m1 PEMGKVYrADrKSVQ
R131 PEMGKVYRADrKSVQ
R134-m1 GKVYrADrKSVQRIK
R139 ADrKSVQRIKARDIV
K169 DIRILSIKSTTLRVD
S170 IRILSIKSTTLRVDQ
S186-p ILTGESVsVIKHTDP
K218 GTNIAAGKAVGIVAT
K234 GVSTEIGKIRDQMAA
K246 MAATEQDKTPLQQKL
K252 DKTPLQQKLDEFGEQ
K328 LGTRRMAKKNAIVRS
K329 GTRRMAKKNAIVRSL
S335 KKNAIVRSLPSVETL
K436 ETKGVYEKVGEATET
S473 ERANACNSVIRQLMK
T484-p QLMKKEFtLEFsRDR
S488-p KEFtLEFsRDRKSMS
K492 LEFsRDRKSMSVYCS
K492 LEFsRDRKSMSVYCS
Y497 DRKSMSVYCSPAKSS
K502 SVYCSPAKSSRAAVG
K511 SRAAVGNKMFVKGAP
K515 VGNKMFVKGAPEGVI
Y527-p GVIDRCNyVRVGTTR
T532 CNyVRVGTTRVPLTG
K542 VPLTGPVKEKIMsVI
K544 LTGPVKEKIMsVIKE
S547-p PVKEKIMsVIKEWGT
K550 EKIMsVIKEWGTGRD
K572 ATRDTPPKREEMVLD
S581-p EEMVLDDsAKFMEYE
K605 GMLDPPRKEVTGSIQ
T608 DPPRKEVTGSIQLCR
T625-p GIRVIMItGDNKGTA
K629 IMItGDNKGTAIAIC
S643-p CRRIGIFsENEEVAD
K712 VNDAPALKKAEIGIA
K713 NDAPALKKAEIGIAM
S722 EIGIAMGSGTAVAKT
T724 GIAMGSGTAVAKTAS
S731 TAVAKTASEMVLADD
K758 RAIYNNMKQFIRYLI
  rabbit

 
K7 _MEAAHSKSTEECLA
S19 CLAYFGVSETTGLTP
K30 GLTPDQVKRHLEKYG
K35 QVKRHLEKYGHNELP
K120 ENAIEALKEYEPEMG
K128 EYEPEMGKVYRADRK
R131 PEMGKVYRADRKSVQ
R131 PEMGKVYRADRKSVQ
R134 GKVYRADRKSVQRIK
R139 ADRKSVQRIKARDIV
K169 DIRILSIKSTTLRVD
S170 IRILSIKSTTLRVDQ
S186 ILTGESVSVIKHTEP
K218 GTNIAAGKALGIVAT
K234 GVSTEIGKIRDQMAA
K246 MAATEQDKTPLQQKL
K252 DKTPLQQKLDEFGEQ
K328 LGTRRMAKKNAIVRS
K329 GTRRMAKKNAIVRSL
S335 KKNAIVRSLPSVETL
K436 ETKGVYEKVGEATET
S473 ERANACNSVIRQLMK
T484 QLMKKEFTLEFSRDR
S488 KEFTLEFSRDRKSMS
K492 LEFSRDRKSMSVYCS
K492 LEFSRDRKSMSVYCS
Y497 DRKSMSVYCSPAKSS
K502 SVYCSPAKSSRAAVG
K511 SRAAVGNKMFVKGAP
K515 VGNKMFVKGAPEGVI
Y527 GVIDRCNYVRVGTTR
T532 CNYVRVGTTRVPMTG
K542 VPMTGPVKEKILSVI
K544 MTGPVKEKILSVIKE
S547 PVKEKILSVIKEWGT
K550 EKILSVIKEWGTGRD
K572 ATRDTPPKREEMVLD
S581 EEMVLDDSSRFMEYE
K605 GMLDPPRKEVMGSIQ
M608 DPPRKEVMGSIQLCR
T625 GIRVIMITGDNKGTA
K629 IMITGDNKGTAIAIC
G643 CRRIGIFGENEEVAD
K712 VNDAPALKKAEIGIA
K713 NDAPALKKAEIGIAM
S722 EIGIAMGSGTAVAKT
T724 GIAMGSGTAVAKTAS
S731 TAVAKTASEMVLADD
K758 RAIYNNMKQFIRYLI
  cow

 
K7 _MEAAHSKTTEECLA
S19 CLAYFGVSETTGLTP
K30 GLTPDQVKRHLEKYG
K35 QVKRHLEKYGHNELP
K120 ENAIEALKEYEPEMG
K128 EYEPEMGKVYRADRK
R131 PEMGKVYRADRKSVQ
R131 PEMGKVYRADRKSVQ
R134 GKVYRADRKSVQRIK
R139 ADRKSVQRIKARDIV
K169 DIRILTIKSTTLRVD
S170 IRILTIKSTTLRVDQ
S186 ILTGESVSVIKHTEP
K218 GTNIAAGKAIGIVAT
K234 GVGTEIGKIRDQMAA
K246 MAATEQDKTPLQQKL
K252 DKTPLQQKLDEFGEQ
K328 LGTRRMAKKNAIVRS
K329 GTRRMAKKNAIVRSL
S335 KKNAIVRSLPSVETL
K436 ETKGIYEKVGEATET
S473 ERANACNSVIRQLMK
T484 QLMKKEFTLEFSRDR
S488 KEFTLEFSRDRKSMS
K492 LEFSRDRKSMSVYCS
K492 LEFSRDRKSMSVYCS
Y497 DRKSMSVYCSPAKSR
K502 SVYCSPAKSRAAVGN
K510 SRAAVGNKMFVKGAP
K514 VGNKMFVKGAPEGVI
Y526 GVIDRCNYVRVGTTR
T531 CNYVRVGTTRVPMTG
K541 VPMTGPVKEKILSVI
K543 MTGPVKEKILSVIKE
S546 PVKEKILSVIKEWGT
K549 EKILSVIKEWGTGRD
K571 ATRDTPPKREEMVLD
S580 EEMVLDDSTKFMEYE
K604 GMLDPPRKEVMGSIQ
M607 DPPRKEVMGSIQLCR
T624 GIRVIMITGDNKGTA
K628 IMITGDNKGTAIAIC
G642 CRRIGIFGENEDVAD
K711 VNDAPALKKAEIGIA
K712 NDAPALKKAEIGIAM
S721 EIGIAMGSGTAVAKT
T723 GIAMGSGTAVAKTAS
S730 TAVAKTASEMVLADD
K757 RAIYNNMKQFIRYLI
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