Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Akt2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Akt2 an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; AKT family
Cellular Component: intracellular membrane-bound organelle; membrane; cytoplasm; plasma membrane; cell cortex; cytosol; nucleus; vesicle
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: glycogen metabolic process; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; apoptosis; multicellular organismal development; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; positive regulation of vesicle fusion; negative regulation of caspase activity; protein amino acid phosphorylation; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; transport; protein kinase B signaling cascade; activation of Ral GTPase; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; carbohydrate metabolic process; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; phosphorylation; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  Q60823 (UniProtKB)
Alt. Names/Synonyms: 2410016A19Rik; Akt2; AW554154; MGC14031; OTTMUSP00000017783; OTTMUSP00000017784; OTTMUSP00000017785; PKB; PKB beta; PKBbeta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2
Gene Symbols: Akt2
Molecular weight: 55,742 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Akt2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Reactome  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K30 RPRYFLLKSDGSFIG
0 2 S34 FLLKSDGSFIGYKER
0 1 Y38 SDGSFIGYKERPEAP
0 1 T81 VIRCLQWTTVIERTF
0 2 Y122 PGEDAMDYKCGsPSD
2 7 S126-p AMDYKCGsPSDsSTS
1 0 S128 DYKCGsPSDsSTSEM
0 1 S130-p KCGsPSDsSTSEMME
1 0 S131 CGsPSDsSTSEMMEV
0 1 N141 EMMEVAVNKARAKVT
0 1 Y177 REKATGRYYAMKILR
0 1 Y178 EKATGRYYAMKILRK
0 1 S242 GELFFHLSRERVFTE
0 1 Y255-p TEDRARFyGAEIVsA
0 1 S261-p FyGAEIVsALEyLHS
0 1 Y265-p EIVsALEyLHSRDVV
0 1 K277 DVVYRDIKLENLMLD
0 3 S302 GLCKEGISDGAtMKt
0 8 T306-p EGISDGAtMKtFCGt
9 19 T309-p SDGAtMKtFCGtPEY
0 4 T313-p tMKtFCGtPEYLAPE
0 12 Y316 tFCGtPEYLAPEVLE
0 27 Y327-p EVLEDNDyGRAVDWW
0 1 K378 RTLGPEAKSLLAGLL
0 1 K378 RTLGPEAKSLLAGLL
0 2 S379 TLGPEAKSLLAGLLK
0 4 Y438 TSEVDTRYFDDEFTA
0 2 S447-p DDEFTAQsITItPPD
0 1 T449 EFTAQsITItPPDRy
1 18 T451-p TAQsITItPPDRyDs
0 2 Y456-p TItPPDRyDsLDPLE
0 4 S458-p tPPDRyDsLDPLELD
16 52 S474-p RTHFPQFsysAsIRE
0 22 Y475-p THFPQFsysAsIRE_
0 9 S476-p HFPQFsysAsIRE__
0 49 S478-p PQFsysAsIRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
8599 : Phospho-Akt2 (Ser474) (D3H2) Rabbit mAb (Akt2 Specific)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
  human

 
K30-ub RPRYFLLkSDGsFIG
S34-p FLLkSDGsFIGyKER
Y38-p SDGsFIGyKERPEAP
T81-p VIRCLQWtTVIERTF
Y122-p PGEDPMDyKCGsPsD
S126-p PMDyKCGsPsDSsTT
S128-p DyKCGsPsDSsTTEE
S130 KCGsPsDSsTTEEME
S131-p CGsPsDSsTTEEMEV
S141-p EEMEVAVsKARAKVT
Y177-p REKATGRyyAMKILR
Y178-p EKATGRyyAMKILRK
S242-p GELFFHLsRERVFTE
Y255 TEERARFYGAEIVSA
S261 FYGAEIVSALEYLHS
Y265 EIVSALEYLHSRDVV
K277-ub DVVYRDIkLENLMLD
S302-p GLCKEGIsDGAtMKt
T306-p EGIsDGAtMKtFCGt
T309-p sDGAtMKtFCGtPEy
T313-p tMKtFCGtPEyLAPE
Y316-p tFCGtPEyLAPEVLE
Y327-p EVLEDNDyGRAVDWW
K378-ac RTLSPEAksLLAGLL
K378-ub RTLSPEAksLLAGLL
S379-p TLSPEAksLLAGLLK
Y438-p TSEVDTRyFDDEFTA
S447-p DDEFTAQsItItPPD
T449-p EFTAQsItItPPDRy
T451-p TAQsItItPPDRyDs
Y456-p tItPPDRyDsLGLLE
S458-p tPPDRyDsLGLLELD
S474-p RTHFPQFsysAsIRE
Y475-p THFPQFsysAsIRE_
S476-p HFPQFsysAsIRE__
S478-p PQFsysAsIRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
8599 : Phospho-Akt2 (Ser474) (D3H2) Rabbit mAb (Akt2 Specific)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
  rat

 
K30 RPRYFLLKSDGSFIG
S34 FLLKSDGSFIGYKER
Y38 SDGSFIGYKERPEAP
T81 VIRCLQWTTVIERTF
Y122 PGEDAMDYKCGSPSD
S126 AMDYKCGSPSDSSTS
S128 DYKCGSPSDSSTSEM
S130 KCGSPSDSSTSEMME
S131 CGSPSDSSTSEMMEV
S141 EMMEVAVSKARAKVT
Y177 REKATGRYYAMKILR
Y178 EKATGRYYAMKILRK
S242 GDLFFHLSRERVFTE
Y255 TEDRARFYGAEIVSA
S261 FYGAEIVSALEYLHS
Y265 EIVSALEYLHSTDVV
K277 DVVYRDIKLENLMLD
S302 GLSKEGISDGATMKt
T306 EGISDGATMKtFCGT
T309-p SDGATMKtFCGTPEY
T313 TMKtFCGTPEYLAPE
Y316 tFCGTPEYLAPEVLE
Y327 EVLEDNDYGRAVDWW
K378 RTLGPEAKSLLAGLL
K378 RTLGPEAKSLLAGLL
S379 TLGPEAKSLLAGLLK
Y438 TSEVDTRYFDDEFTA
S447 DDEFTAQSITITPPD
T449 EFTAQSITITPPDRY
T451 TAQSITITPPDRYDS
Y456 TITPPDRYDSLGSLE
S458 TPPDRYDSLGSLELD
S474-p RTHFPQFsYSASIRE
Y475 THFPQFsYSASIRE_
S476 HFPQFsYSASIRE__
S478 PQFsYSASIRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
8599 : Phospho-Akt2 (Ser474) (D3H2) Rabbit mAb (Akt2 Specific)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.