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Akt2 (mouse)

Overview Akt2 an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB. Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; AGC group; AKT family Cellular Component: membrane; intracellular membrane-bound organelle; lamellipodium; cytoplasm; plasma membrane; nucleus; cytosol; vesicle Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phospholipid binding; kinase activity; ATP binding; protein kinase activity Biological Process: glycogen metabolic process; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; apoptosis; multicellular organismal development; positive regulation of glycogen biosynthetic process; negative regulation of caspase activity; regulation of JNK cascade; protein amino acid phosphorylation; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; transport; protein kinase B signaling cascade; activation of Ral GTPase; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; carbohydrate metabolic process; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; phosphorylation; positive regulation of cell migration; negative regulation of apoptosis Reference #:  Q60823 (UniProtKB) Alt. Names/Synonyms: 2410016A19Rik; Akt2; AW554154; MGC14031; OTTMUSP00000017783; OTTMUSP00000017784; OTTMUSP00000017785; PKB; PKB beta; PKBbeta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2 Gene Symbols: Akt2 Molecular weight: 55,742 Da Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Akt2 1GZK - A=146-460 (human) 1GZN - A=146-480 (human) 1GZO - A=146-460 (human) 1MRV - A=143-481 (human) 1MRY - A=143-481 (human) 1O6K - A=146-481 (human) 1O6L - A=146-467 (human) 1P6S - A=1-111 (human) 2UW9 - A=146-477 (human) 2X39 - A=146-467 (human) 2XH5 - A=146-479 (human) 3D0E - A/B=146-480 (human) 3E87 - A/B=146-480 (human) 3E88 - A/B=146-480 (human) 3E8D - A/B=146-480 (human) Substrate Sequence Logo

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		K30	RPRYFLLKSDGSFIG
0	1		Y38	SDGSFIGYKERPEAP
0	1		T81	VIRCLQWTTVIERTF
1	4		S126-p	AMDYKCGsPSDsSTS
0	1		S130-p	KCGsPSDsSTSEMME
0	1		Y177	REKATGRYYAMKILR
0	1		Y178	EKATGRYYAMKILRK
0	1		S242	GELFFHLSRERVFTE
0	1		Y255-p	TEDRARFyGAEIVsA
0	1		S261-p	FyGAEIVsALEyLHS
0	1		Y265-p	EIVsALEyLHSRDVV
0	1		K277	DVVYRDIKLENLMLD
0	3		S302	GLCKEGISDGAtMKt
0	7		T306-p	EGISDGAtMKtFCGt
9	14		T309-p	SDGAtMKtFCGtPEY
0	4		T313-p	tMKtFCGtPEYLAPE
0	12		Y316	tFCGtPEYLAPEVLE
0	26		Y327-p	EVLEDNDyGRAVDWW
0	1		K378	RTLGPEAKSLLAGLL
0	1		K378	RTLGPEAKSLLAGLL
0	1		S379	TLGPEAKSLLAGLLK
0	3		Y438	TSEVDTRYFDDEFTA
0	2		S447-p	DDEFTAQsITItPPD
0	1		T449	EFTAQsITItPPDRY
1	16		T451-p	TAQsITItPPDRYDs
0	1		Y456	TItPPDRYDsLDPLE
0	3		S458-p	tPPDRYDsLDPLELD
16	46		S474-p	RTHFPQFsysAsIRE
0	18		Y475-p	THFPQFsysAsIRE_
0	8		S476-p	HFPQFsysAsIRE__
0	43		S478-p	PQFsysAsIRE____

	human
K30-u	RPRYFLLkSDGSFIG
Y38-p	SDGSFIGyKERPEAP
T81-p	VIRCLQWtTVIERTF
S126-p	PMDYKCGsPSDSSTT
S130	KCGsPSDSSTTEEME
Y177-p	REKATGRyyAMKILR
Y178-p	EKATGRyyAMKILRK
S242-p	GELFFHLsRERVFTE
Y255	TEERARFYGAEIVSA
S261	FYGAEIVSALEYLHS
Y265	EIVSALEYLHSRDVV
K277-u	DVVYRDIkLENLMLD
S302-p	GLCKEGIsDGAtMKt
T306-p	EGIsDGAtMKtFCGt
T309-p	sDGAtMKtFCGtPEy
T313-p	tMKtFCGtPEyLAPE
Y316-p	tFCGtPEyLAPEVLE
Y327-p	EVLEDNDyGRAVDWW
K378-a	RTLSPEAksLLAGLL
K378-u	RTLSPEAksLLAGLL
S379-p	TLSPEAksLLAGLLK
Y438-p	TSEVDTRyFDDEFTA
S447-p	DDEFTAQsItItPPD
T449-p	EFTAQsItItPPDRy
T451-p	TAQsItItPPDRyDs
Y456-p	tItPPDRyDsLGLLE
S458-p	tPPDRyDsLGLLELD
S474-p	RTHFPQFsysAsIRE
Y475-p	THFPQFsysAsIRE_
S476-p	HFPQFsysAsIRE__
S478-p	PQFsysAsIRE____

	rat
K30	RPRYFLLKSDGSFIG
Y38	SDGSFIGYKERPEAP
T81	VIRCLQWTTVIERTF
S126	AMDYKCGSPSDSSTS
S130	KCGSPSDSSTSEMME
Y177	REKATGRYYAMKILR
Y178	EKATGRYYAMKILRK
S242	GDLFFHLSRERVFTE
Y255	TEDRARFYGAEIVSA
S261	FYGAEIVSALEYLHS
Y265	EIVSALEYLHSTDVV
K277	DVVYRDIKLENLMLD
S302	GLSKEGISDGATMKt
T306	EGISDGATMKtFCGT
T309-p	SDGATMKtFCGTPEY
T313	TMKtFCGTPEYLAPE
Y316	tFCGTPEYLAPEVLE
Y327	EVLEDNDYGRAVDWW
K378	RTLGPEAKSLLAGLL
K378	RTLGPEAKSLLAGLL
S379	TLGPEAKSLLAGLLK
Y438	TSEVDTRYFDDEFTA
S447	DDEFTAQSITITPPD
T449	EFTAQSITITPPDRY
T451	TAQSITITPPDRYDS
Y456	TITPPDRYDSLGSLE
S458	TPPDRYDSLGSLELD
S474-p	RTHFPQFsYSASIRE
Y475	THFPQFsYSASIRE_
S476	HFPQFsYSASIRE__
S478	PQFsYSASIRE____

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