an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; AKT family
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: glycogen metabolic process; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; apoptosis; multicellular organismal development; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; positive regulation of vesicle fusion; negative regulation of caspase activity; protein amino acid phosphorylation; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; transport; protein kinase B signaling cascade; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; carbohydrate metabolic process; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; phosphorylation; negative regulation of apoptosis; positive regulation of cell migration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.